caa a22 4500 445388692 CHVBK 20180317143039.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11144-010-0249-0 doi (NATIONALLICENCE)springer-10.1007/s11144-010-0249-0 Catalytic effect of buffers on the degradation of doripenem in aqueous solutions [Elektronische Daten] [Judyta Cielecka-Piontek, Anna Jelińska] The catalytic effect of buffers (phosphate, acetate, borate, carbonate) on the degradation of doripenem in aqueous solutions was studied at 313K in the pH range 0.82-11.56 (μ=0.50molL−1) by an HPLC-UV method developed for kinetic studies of doripenem. It was observed that general acid-base catalysis occurred in all buffers and so catalytic rate constants were calculated. Specific acid-base catalysis of doripenem involved degradation of protonated molecules and zwitter ions of doripenem catalyzed by hydrogen ions, spontaneous degradation of zwitter ions under the influence of water and degradation of zwitter ions and monoanions catalyzed by hydroxide ions. The Author(s), 2010 Doripenem nationallicence Catalytic effect of buffers nationallicence Catalytic rate constants nationallicence pH-rate profile nationallicence Cielecka-Piontek Judyta Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland aut Jelińska Anna Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland aut Reaction Kinetics, Mechanisms and Catalysis Springer Netherlands 102/1(2011-02-01), 37-47 1878-5190 102:1<37 2011 102 11144 https://doi.org/10.1007/s11144-010-0249-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11144-010-0249-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cielecka-Piontek Judyta Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland aut NATIONALLICENCE 700 1- Jelińska Anna Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznań, Poland aut NATIONALLICENCE 773 0- Reaction Kinetics, Mechanisms and Catalysis Springer Netherlands 102/1(2011-02-01), 37-47 1878-5190 102:1<37 2011 102 11144 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer