caa a22 4500 445391464 CHVBK 20180317143048.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10955-011-0199-6 doi (NATIONALLICENCE)springer-10.1007/s10955-011-0199-6 Speeding up Evolutionary Search by Small Fitness Fluctuations [Elektronische Daten] [Jakub Otwinowski, Sorin Tanase-Nicola, Ilya Nemenman] We consider a fixed size population that undergoes an evolutionary adaptation in the weak mutation rate limit, which we model as a biased Langevin process in the genotype space. We show analytically and numerically that, if the fitness landscape has a small highly epistatic (rough) and time-varying component, then the population genotype exhibits a high effective diffusion in the genotype space and is able to escape local fitness minima with a large probability. We argue that our principal finding that even very small time-dependent fluctuations of fitness can substantially speed up evolution is valid for a wide class of models. The Author(s), 2011 Stochastic process nationallicence Nonequilibrium nationallicence Barrier crossing nationallicence Fixation nationallicence Otwinowski Jakub Department of Physics, Emory University, 30322, Atlanta, GA, USA aut Tanase-Nicola Sorin Department of Physics, Emory University, 30322, Atlanta, GA, USA aut Nemenman Ilya Departments of Physics and Biology and Computational and Life Sciences Initiative, Emory University, 30322, Atlanta, GA, USA aut Journal of Statistical Physics Springer US; http://www.springer-ny.com 144/2(2011-07-01), 367-378 0022-4715 144:2<367 2011 144 10955 https://doi.org/10.1007/s10955-011-0199-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10955-011-0199-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Otwinowski Jakub Department of Physics, Emory University, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Tanase-Nicola Sorin Department of Physics, Emory University, 30322, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Nemenman Ilya Departments of Physics and Biology and Computational and Life Sciences Initiative, Emory University, 30322, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Journal of Statistical Physics Springer US; http://www.springer-ny.com 144/2(2011-07-01), 367-378 0022-4715 144:2<367 2011 144 10955 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer