caa a22 4500 445391529 CHVBK 20180317143048.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s10955-011-0251-6 doi (NATIONALLICENCE)springer-10.1007/s10955-011-0251-6 Molecular and Functional Aspects of Bacterial Chemotaxis [Elektronische Daten] [A. Celani, T. Shimizu, M. Vergassola] We consider the dynamics of chemotaxis in the model bacterium Escherichia coli. We analyze both its molecular mechanisms and the functional causes governing the evolution of the observed behaviors. We review molecular models of the transduction network controlling the bacterial chemotaxis in response to chemoattractant binding to the receptors. In particular, recent progress stimulated by FRET experiments is presented for statistical physics allosteric models. The response function to a pulse of chemoattractant is expressed in terms of microscopic parameters of the allosteric models. The functional causes for the shape of the response function, as measured in experimental tethering assay, are then investigated. A hydrodynamic equation, valid for space-time scales larger than the microscopic running length and time, is derived for the position of a swimming bacterium. It is then shown how optimization over the microscopic parameters of the response function yields the curve observed experimentally. In particular, the observed property of adaptation to the background level of aspartate emerges as being produced by fluctuations in the space-time chemoattractant profiles sensed by bacteria along their trajectories. This functional cause is distinct from arguments based on the extension of the dynamical range. Future directions and experiments to probe the adaptation of E. coli chemotaxis to the environmental conditions and its response to realistic space-time chemoattractant stimuli are finally discussed. Springer Science+Business Media, LLC, 2011 Bacterial chemotaxis nationallicence Adaptation nationallicence Hydrodynamic limit nationallicence Homogenization methods nationallicence Celani A. Research Unit "Physics of Biological Systems” and CNRS, URA 2171, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris Cedex 15, France aut Shimizu T. FOM Institute for Atomic and Molecular Physics (AMOLF), Science Park 104, 1098 XG, Amsterdam, The Netherlands aut Vergassola M. Research Unit "Physics of Biological Systems” and CNRS, URA 2171, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris Cedex 15, France aut Journal of Statistical Physics Springer US; http://www.springer-ny.com 144/2(2011-07-01), 219-240 0022-4715 144:2<219 2011 144 10955 https://doi.org/10.1007/s10955-011-0251-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10955-011-0251-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Celani A. Research Unit "Physics of Biological Systems” and CNRS, URA 2171, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris Cedex 15, France aut NATIONALLICENCE 700 1- Shimizu T. FOM Institute for Atomic and Molecular Physics (AMOLF), Science Park 104, 1098 XG, Amsterdam, The Netherlands aut NATIONALLICENCE 700 1- Vergassola M. Research Unit "Physics of Biological Systems” and CNRS, URA 2171, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris Cedex 15, France aut NATIONALLICENCE 773 0- Journal of Statistical Physics Springer US; http://www.springer-ny.com 144/2(2011-07-01), 219-240 0022-4715 144:2<219 2011 144 10955 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer