caa a22 4500 445391685 CHVBK 20180317143048.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10955-011-0156-4 doi (NATIONALLICENCE)springer-10.1007/s10955-011-0156-4 Quantifying Information Transmission in Eukaryotic Gradient Sensing and Chemotactic Response [Elektronische Daten] [Bo Hu, Wen Chen, Herbert Levine, Wouter-Jan Rappel] Eukaryotic cells are able to sense shallow chemical gradients by surface receptors and migrate toward chemoattractant sources. The accuracy of this chemotactic response relies on the ability of cells to infer gradients from the heterogeneous distribution of receptors bound by diffusing chemical molecules. Ultimately, the precision of gradient sensing is limited by the fluctuations of signaling components, including the stochastic receptor occupancy and noisy intracellular processing. Viewing the system as a Markovian communication channel, we apply techniques from information theory to derive upper bounds on the amount of information that can be reliably transmitted through a chemotactic cell. Specifically, we derive an expression for the mutual information between the gradient direction and the spatial distribution of bound receptors. We also compute the mutual information between the gradient direction and the motility direction using three different models for cell motion. Our results can be used to quantify the information loss during the various stages of directional sensing in eukaryotic chemotaxis. The Author(s), 2011 Chemotaxis nationallicence Stochasticity nationallicence Mutual information nationallicence Hu Bo Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 92093-0374, La Jolla, CA, USA aut Chen Wen Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 92093-0374, La Jolla, CA, USA aut Levine Herbert Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 92093-0374, La Jolla, CA, USA aut Rappel Wouter-Jan Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 92093-0374, La Jolla, CA, USA aut Journal of Statistical Physics Springer US; http://www.springer-ny.com 142/6(2011-04-01), 1167-1186 0022-4715 142:6<1167 2011 142 10955 https://doi.org/10.1007/s10955-011-0156-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10955-011-0156-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hu Bo Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 92093-0374, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Chen Wen Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 92093-0374, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Levine Herbert Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 92093-0374, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Rappel Wouter-Jan Center for Theoretical Biological Physics and Department of Physics, University of California at San Diego, 92093-0374, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Journal of Statistical Physics Springer US; http://www.springer-ny.com 142/6(2011-04-01), 1167-1186 0022-4715 142:6<1167 2011 142 10955 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer