caa a22 4500 445391766 CHVBK 20180317143049.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10955-011-0174-2 doi (NATIONALLICENCE)springer-10.1007/s10955-011-0174-2 Arrhenius Lifetimes of RNA Structures from Free Energy Landscapes [Elektronische Daten] [Ben Sauerwine, Michael Widom] We develop a novel method to define an effective free energy barrier between various conformations available to an RNA sequence. Our approach utilizes the energy landscape computed using the ViennaRNA package. Replacing the energies with configurational free energies yields improved agreement with the Arrhenius law provided we account for the entropies of both the basin states and the barrier states. This improved agreement comes without altering the computational complexity class of the algorithm. We discuss the combinatorial explosion of high-energy states available to RNA, and the properties of Kawasaki and Metropolis transition models that affect the applicability our method. Springer Science+Business Media, LLC, 2011 RNA nationallicence Kinetic nationallicence Arrhenius nationallicence Lifetime nationallicence Sauerwine Ben Carnegie Mellon University, Pittburg, USA aut Widom Michael Carnegie Mellon University, Pittburg, USA aut Journal of Statistical Physics Springer US; http://www.springer-ny.com 142/6(2011-04-01), 1337-1352 0022-4715 142:6<1337 2011 142 10955 https://doi.org/10.1007/s10955-011-0174-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10955-011-0174-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sauerwine Ben Carnegie Mellon University, Pittburg, USA aut NATIONALLICENCE 700 1- Widom Michael Carnegie Mellon University, Pittburg, USA aut NATIONALLICENCE 773 0- Journal of Statistical Physics Springer US; http://www.springer-ny.com 142/6(2011-04-01), 1337-1352 0022-4715 142:6<1337 2011 142 10955 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer