caa a22 4500 445391804 CHVBK 20180317143049.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10955-010-0069-7 doi (NATIONALLICENCE)springer-10.1007/s10955-010-0069-7 How Interactions Control Molecular Transport inChannels [Elektronische Daten] [Anatoly Kolomeisky, Karthik Uppulury] The motion of molecules across channels and pores is critically important for understanding mechanisms of many cellular processes. Here we investigate the mechanism of interactions in the molecular transport through nanopores by analyzing exactly solvable discrete stochastic models. According to this approach the channel transport is viewed as a set of chemical transitions between discrete states. It is shown that the strength and spatial distribution of molecule/channel interactions can strongly modify the particle current. Our analysis indicates that the most optimal transport is achieved when the binding sites are near the entrance or exit of the pore depending on the sign of interaction potential. In addition, the role of intermolecular interactions during the channel transport is studied, and it is argued that an increase in the flux can be observed for some optimal interaction strength. The mechanisms of these phenomena are discussed. Springer Science+Business Media, LLC, 2010 Molecular transport nationallicence Discrete stochastic models nationallicence Nanopores nationallicence Intermolecular interactions nationallicence Kolomeisky Anatoly Department of Chemistry, Rice University, 6100 Main Street, Houston, TX, USA aut Uppulury Karthik Department of Chemistry, Rice University, 6100 Main Street, Houston, TX, USA aut Journal of Statistical Physics Springer US; http://www.springer-ny.com 142/6(2011-04-01), 1268-1276 0022-4715 142:6<1268 2011 142 10955 https://doi.org/10.1007/s10955-010-0069-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10955-010-0069-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kolomeisky Anatoly Department of Chemistry, Rice University, 6100 Main Street, Houston, TX, USA aut NATIONALLICENCE 700 1- Uppulury Karthik Department of Chemistry, Rice University, 6100 Main Street, Houston, TX, USA aut NATIONALLICENCE 773 0- Journal of Statistical Physics Springer US; http://www.springer-ny.com 142/6(2011-04-01), 1268-1276 0022-4715 142:6<1268 2011 142 10955 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer