caa a22 4500 445794542 CHVBK 20180317145120.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10620-011-1763-2 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1763-2 In PSC with Colitis Treated with UDCA, Most Colonic Carcinomas Develop in the First Years After the Start of Treatment [Elektronische Daten] [G. Rudolph, D. Gotthardt, P. Kloeters-Plachky, H. Kulaksiz, P. Schirmacher, A. Stiehl] Background: Patients with PSC and IBD have a high incidence of colonic carcinomas (CRC), and the annual incidence of CRC increases with duration of disease. UDCA treatment has been suggested to reduce colonic dysplasias and carcinomas. Aims: The annual incidence of colorectal carcinomas after long-term UDCA treatment was studied. Methods: Patients included in a prospective study on the outcome after ursodeoxycholic acid (UDCA) treatment were evaluated. Results: A total of 120 of 171 PSC patients included had IBD (108 UC and 12 CD). All patients were treated with UDCA for a median time of 6.7years. Seven patients with PSC and IBD developed a CRC yielding a prevalence of 5.8%. In years 0-3 (n=120) after the start of UDCA, the annual incidence rate of CRC was 0.62/100 patient years; in years 3-6 (n=93) it increased to 1.28 and decreased thereafter in years 6-9 (n=67) to 1.17, then in years 9-12 (n=42) to 0 and after>12years (n=24) it remained 0. In PSC with IBD, Kaplan-Meier estimate of CRC formation increased with time in the first years of treatment and reached a plateau after 9years; after treatment for≥9years, no further CRC were observed. Conclusion: After the start of UDCA, the annual incidence of CRC increased up to 6years and subsequently decreased. In PSC with IBD treated with UDCA, most colonic carcinomas develop in the first years after the start of treatment. Springer Science+Business Media, LLC, 2011 Sclerosing cholangitis nationallicence Inflammatory bowel disease nationallicence Colonic carcinomas nationallicence Ursodeoxycholic acid nationallicence PSC : Primary sclerosing cholangitis nationallicence IBD : Inflammatory bowel disease nationallicence UDCA : Ursodeoxycholic acid nationallicence Rudolph G. Department of Medicine, University of Heidelberg, Medizinische Universitätsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany aut Gotthardt D. Department of Medicine, University of Heidelberg, Medizinische Universitätsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany aut Kloeters-Plachky P. Department of Medicine, University of Heidelberg, Medizinische Universitätsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany aut Kulaksiz H. Department of Medicine, University of Ulm, Ulm, Germany aut Schirmacher P. Department of Pathology, University of Heidelberg, Heidelberg, Germany aut Stiehl A. Department of Medicine, University of Heidelberg, Medizinische Universitätsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3624-3630 0163-2116 56:12<3624 2011 56 10620 https://doi.org/10.1007/s10620-011-1763-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1763-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rudolph G. Department of Medicine, University of Heidelberg, Medizinische Universitätsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Gotthardt D. Department of Medicine, University of Heidelberg, Medizinische Universitätsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Kloeters-Plachky P. Department of Medicine, University of Heidelberg, Medizinische Universitätsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany aut NATIONALLICENCE 700 1- Kulaksiz H. Department of Medicine, University of Ulm, Ulm, Germany aut NATIONALLICENCE 700 1- Schirmacher P. Department of Pathology, University of Heidelberg, Heidelberg, Germany aut NATIONALLICENCE 700 1- Stiehl A. Department of Medicine, University of Heidelberg, Medizinische Universitätsklinik, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3624-3630 0163-2116 56:12<3624 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer