caa a22 4500 445794569 CHVBK 20180317145120.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10620-011-1760-5 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1760-5 Serum Interleukin-33 Levels in Patients with Gastric Cancer [Elektronische Daten] [Pinghu Sun, Qiwen Ben, Shuiping Tu, Wenjie Dong, Xiaoguang Qi, Yunlin Wu] Background: Interleukin-33 (IL-33) is a novel member of the IL-1 family of cytokines, and it is closely related to IL-18, one of the best characterized members of the IL-1 family. It's been demonstrated that elevated levels of IL-18 are involved in a wide variety of tumors, especially in gastric cancer. Aims: The purpose of this study was to determine the correlations between serum IL-33 levels and the clinicopathologic features in gastric cancer patients. Methods: Serum samples were collected from 68 patients with gastric cancer and 57 controls. Serum IL-33 levels were measured by ELISA. Classical tumor markers of CEA and CA19-9 levels were routinely detected by chemiluminescence immunoassay. Western blot analysis was used to detect IL-33 expression in gastric cancer tissue samples and cell lines. The relationship between serum levels of IL-33 and clinical characteristics in patients was analyzed. Results: IL-33 levels in the serum of gastric cancer patients were significantly elevated in comparison with that of healthy volunteers. Furthermore, higher serum levels of IL-33 in gastric cancer patients were found to correlate with several poor prognostic factors like depth of invasion, distant metastasis and advanced stage (stage III/IV). On the other hand, serum IL-33 levels did not correlate with CEA and CA19-9. The expression of IL-33 protein was upregulated in carcinoma tissues in comparison with matched normal tissues, and no statistically significant difference was found between the four gastric cancer cell lines and human gastric epithelial cell line GES-1. Conclusions: Serum IL-33 may be a useful biomarker for predicting the prognosis of gastric cancer. Springer Science+Business Media, LLC, 2011 Interleukin-33 nationallicence Gastric cancer nationallicence ELISA nationallicence Prognosis nationallicence Sun Pinghu Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut Ben Qiwen Department of Gastroenterology, Changhai Hospital of Second Military Medical University, 168 Changhai Road, 200433, Shanghai, People's Republic of China aut Tu Shuiping Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut Dong Wenjie Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut Qi Xiaoguang Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut Wu Yunlin Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3596-3601 0163-2116 56:12<3596 2011 56 10620 https://doi.org/10.1007/s10620-011-1760-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1760-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sun Pinghu Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Ben Qiwen Department of Gastroenterology, Changhai Hospital of Second Military Medical University, 168 Changhai Road, 200433, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Tu Shuiping Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Dong Wenjie Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Qi Xiaoguang Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Wu Yunlin Department of Gastroenterology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin No.2 Road, 200025, Shanghai, People's Republic of China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3596-3601 0163-2116 56:12<3596 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer