caa a22 4500 445794585 CHVBK 20180317145120.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10620-011-1812-x doi (NATIONALLICENCE)springer-10.1007/s10620-011-1812-x Clinical Impact of HAb18G/CD147 Expression in Esophageal Squamous Cell Carcinoma [Elektronische Daten] [Shaojun Zhu, Yanhong Li, Li Mi, Yang Zhang, Li Zhang, Li Gong, Xiujuan Han, Li Yao, Miao Lan, Zhinan Chen, Wei Zhang] Background: HAb18G/CD147 expression has been associated with many tumor invasion molecules, which play important roles in recurrence and poor differentiation of esophageal squamous cell carcinoma (ESCC). However, the clinical implications of HAb18G/CD147 in ESCC are still unclear. Aims: In this study, we clarified the clinical significance of HAb18G/CD147 and characterized the association between HAb18G/CD147 and tumor invasion in ESCC cases. Methods: Tumor tissues were obtained from 86 ESCC patients who underwent surgical resection between 2002 and 2005. All patients that had received previous therapy were excluded. ESCC tissues were analyzed by IHC using anti HAb18G/CD147 antibody. The expression of HAb18G/CD147 mRNA in esophageal cancer cell lines was analyzed by RT-PCR. Results: HAb18G/CD147 was uniformly expressed in EC109 and EC871214 cell lines, but negatively expressed in EPC2, esophageal normal squamous cell line. HAb18G/CD147 mainly localized to the membrane of tumor cells in 84.9% of ESCC patients (64 out of 86 cases). Furthermore, we also found that higher HAb18G/CD147 expression levels significantly correlated with lymph node metastasis, depth of tumor invasion and differentiation (P<0.05). But the expression levels of HAb18G/CD147 in lymph node metastatic tissues were almost equal to that in the primary tumor tissues. Furthermore, lymph node metastasis and expression of HAB18G/CD147 were independent prognostic indicators in ESCC. Conclusions: The expression of HAb18G/CD147 might be involved in the progression and survival of ESCC. Therefore, HAb18G/CD147 could be a clinical marker for the poor prognosis in ESCC patients and may also be a potentially therapeutic target to improve the progression of ESCC. Springer Science+Business Media, LLC, 2011 HAb18G/CD147 nationallicence ESCC nationallicence Immunohistochemistry nationallicence Survival nationallicence Zhu Shaojun The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut Li Yanhong The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut Mi Li State Key Laboratory of Cancer Biology, Cell Engineering Research Centre and Department of Cell Biology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, People's Republic of China aut Zhang Yang State Key Laboratory of Cancer Biology, Cell Engineering Research Centre and Department of Cell Biology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, People's Republic of China aut Zhang Li The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut Gong Li The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut Han Xiujuan The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut Yao Li The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut Lan Miao The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut Chen Zhinan State Key Laboratory of Cancer Biology, Cell Engineering Research Centre and Department of Cell Biology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, People's Republic of China aut Zhang Wei The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3569-3576 0163-2116 56:12<3569 2011 56 10620 https://doi.org/10.1007/s10620-011-1812-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1812-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Shaojun The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Li Yanhong The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Mi Li State Key Laboratory of Cancer Biology, Cell Engineering Research Centre and Department of Cell Biology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Yang State Key Laboratory of Cancer Biology, Cell Engineering Research Centre and Department of Cell Biology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Li The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Gong Li The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Han Xiujuan The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Yao Li The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Lan Miao The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 700 1- Chen Zhinan State Key Laboratory of Cancer Biology, Cell Engineering Research Centre and Department of Cell Biology, National Key Discipline of Cell Biology, Fourth Military Medical University, Xi'an, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Wei The Helmholtz Sino-German Research Laboratory for Cancer, Department of Pathology, Tangdu Hospital, Fourth Military Medical University, 710038, Xi'an, Shaanxi, People's Republic of China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3569-3576 0163-2116 56:12<3569 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer