caa a22 4500 445794615 CHVBK 20180317145120.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10620-011-1885-6 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1885-6 Molecular Mechanisms of Barrett's Esophagus [Elektronische Daten] [Hao Chen, Yu Fang, Whitney Tevebaugh, Roy Orlando, Nicholas Shaheen, Xiaoxin Chen] Barrett's esophagus (BE) is defined as the metaplastic conversion of esophageal squamous epithelium to intestinalized columnar epithelium. As a premalignant lesion of esophageal adenocarcinoma (EAC), BE develops as a result of chronic gastroesophageal reflux disease (GERD). Many studies have been conducted to understand the molecular mechanisms of this disease. This review summarizes recent results involving squamous and intestinal transcription factors, signaling pathways, stromal factors, microRNAs, and other factors in the development of BE. A conceptual framework is proposed to guide future studies. We expect elucidation of the molecular mechanisms of BE to help in the development of improved management of GERD, BE, and EAC. Springer Science+Business Media, LLC, 2011 Barrett's esophagus nationallicence Transcription factor nationallicence Signaling pathway nationallicence BE : Barrett's esophagus nationallicence BMP : Bone morphogenetic protein nationallicence EAC : Esophageal adenocarcinoma nationallicence GERD : Gastroesophageal reflux disease nationallicence HNF : Hepatocyte nuclear factor nationallicence KLF : Krüppel-like factor nationallicence NE : Normal esophagus nationallicence RUNX3 : Runt-related transcriptional factor 3 nationallicence SNP : Single nucleotide polymorphism nationallicence Spdef : SAM pointed domain-containing Ets transcription factor nationallicence TGF : Transforming growth factor nationallicence Chen Hao Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, 27707, Durham, NC, USA aut Fang Yu Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, 27707, Durham, NC, USA aut Tevebaugh Whitney Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, 27707, Durham, NC, USA aut Orlando Roy Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, 103 Mason Farm Road, Molecular Biomedical Research Building, CB#7032, 27599, Chapel Hill, NC, USA aut Shaheen Nicholas Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, CB#7080, 27599, Chapel Hill, NC, USA aut Chen Xiaoxin Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, 27707, Durham, NC, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3405-3420 0163-2116 56:12<3405 2011 56 10620 https://doi.org/10.1007/s10620-011-1885-6 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1885-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chen Hao Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, 27707, Durham, NC, USA aut NATIONALLICENCE 700 1- Fang Yu Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, 27707, Durham, NC, USA aut NATIONALLICENCE 700 1- Tevebaugh Whitney Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, 27707, Durham, NC, USA aut NATIONALLICENCE 700 1- Orlando Roy Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, 103 Mason Farm Road, Molecular Biomedical Research Building, CB#7032, 27599, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Shaheen Nicholas Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, CB#7080, 27599, Chapel Hill, NC, USA aut NATIONALLICENCE 700 1- Chen Xiaoxin Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, 700 George Street, 27707, Durham, NC, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3405-3420 0163-2116 56:12<3405 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer