caa a22 4500 445794704 CHVBK 20180317145121.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10620-011-1777-9 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1777-9 Mechanical Characteristics of Distension-Evoked Peristaltic Contractions in the Esophagus of Systemic Sclerosis Patients [Elektronische Daten] [Hans Gregersen, Gerda Villadsen, Donghua Liao] Background: Systemic sclerosis (SS) patients with severe esophageal affection have impaired peristalsis. However, motor function evaluated in vivo by manometry and fluoroscopy does not provide detailed information about the individual contraction cycles. Aims: To apply, for the first time in gastrointestinal (GI) patients, a method and principles modified from cardiac research to study esophageal muscle behavior in SS patients. Methods: Muscle contraction cycles were analyzed using pressure-cross-sectional area (P-CSA) loops during distension pressure up to 5kPa. The probe with bag and electrodes for CSA measurements was positioned 7 and 15cm above the lower esophageal sphincter (LES) in eleven healthy volunteers and eleven SS patients. The P-CSA, the wall tension, Δtension (afterload tension−preload tension), contraction velocity, work output (area of the tension-CSA loops), and power output (preload tension×CSA rate) were analyzed. Results: The P-CSA loops consisted of phases with relaxation and contraction behavior. The tension-stretch ratio loops in patients were shifted to the left at both distension sites, indicative of a stiffer wall in patients. Lower contraction amplitudes and smaller P-CSA loops were observed for the SS patients. The work output, power output, Δtension, and contraction velocity were lower in patients (P<0.001). Association was found between disease duration and the work output, Δtension, and velocity at pressure steps higher than 3kPa (P<0.05). Conclusions: Distension-evoked esophageal contraction can be studied in vivo and analyzed with advanced methods. Increased esophageal stiffness and impaired muscle function that depended on disease duration were observed for SS patients. The analysis may be useful for characterization of other diseases affecting GI function. Springer Science+Business Media, LLC, 2011 Human esophagus nationallicence Systemic sclerosis nationallicence Distension nationallicence Pressure-CSA loop nationallicence Work output nationallicence SS : Systemic sclerosis nationallicence CSA : Cross-sectional area nationallicence LES : Lower esophageal sphincter nationallicence Gregersen Hans Mech-Sense, Aalborg Hospital Science and Innovation Centre, Aarhus University Hospital, Sdr. Skovvej 15, 9000, Aalborg, Denmark aut Villadsen Gerda Department of Gastroenterology V, Aarhus Hospital, Aarhus, Denmark aut Liao Donghua Mech-Sense, Aalborg Hospital Science and Innovation Centre, Aarhus University Hospital, Sdr. Skovvej 15, 9000, Aalborg, Denmark aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3559-3568 0163-2116 56:12<3559 2011 56 10620 https://doi.org/10.1007/s10620-011-1777-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1777-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gregersen Hans Mech-Sense, Aalborg Hospital Science and Innovation Centre, Aarhus University Hospital, Sdr. Skovvej 15, 9000, Aalborg, Denmark aut NATIONALLICENCE 700 1- Villadsen Gerda Department of Gastroenterology V, Aarhus Hospital, Aarhus, Denmark aut NATIONALLICENCE 700 1- Liao Donghua Mech-Sense, Aalborg Hospital Science and Innovation Centre, Aarhus University Hospital, Sdr. Skovvej 15, 9000, Aalborg, Denmark aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3559-3568 0163-2116 56:12<3559 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer