caa a22 4500 445794739 CHVBK 20180317145121.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10620-011-1778-8 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1778-8 Multiparametric Assessment of Vascular Function and Atherosclerosis in Patients with Autoimmune Gastritis: A Comparative Study [Elektronische Daten] [Mustafa Yakut, Yusuf Üstün, Sim Kutlay, Aydan Ongun, Gökhan Kabaçam, Recai Boynueğri, Irfan Soykan] Background/Aims: Patients with autoimmune gastritis might have accelerated atherosclerosis due to autoimmunity and chronic inflammation. Endothelial dysfunction often precedes manifest atherosclerosis. The aim of the present study was to evaluate the risk factors of early atherosclerosis by using several different techniques. Methods: A total of 99 patients with autoimmune gastritis were compared to 42 healthy age sex-matched subjects. Patients with a known risk factor for atherosclerosis were excluded. Intima-media thickness of the common carotid artery, pulse wave velocity and flow-mediated dilation of brachial artery were measured. Clinical data and laboratory parameters (serum gastrin, antiparietal cell antibody, anti-Hp IgG, serum vitamin B12 and lipid profile) were also determined. Results: Intima-media thickness (mm) of the carotid artery was significantly higher in autoimmune gastritis (0.062±0.031 vs. 0.042±0.007, P<0.001) than in healthy individuals. Flow-mediated dilation was significantly lower in patients with autoimmune gastritis compared to control group (13.91±6.68% vs. 20.37±7.80%, P=0.021) and there was a significant increase in pulse wave velocity (m/s) in autoimmune gastritis patients compared to controls (9.25±3.42 vs. 6.40±0.91, P=0.001). Antiparietal cell antibody positivity (P=0.05), low vitamin B12 level (P=0.05), and age (P=0.002) were the predictors of high pulse wave velocity (>14m/s). Conclusion: Patients with autoimmune gastritis may have an increased risk for the development of early atherosclerosis. As early preventive treatment for accelerated atherosclerosis is available, it is important to detect those patients with autoimmune gastritis who would benefit from such treatment. Springer Science+Business Media, LLC, 2011 Autoimmune gastritis nationallicence Pulse wave velocity nationallicence Intima-media thickness nationallicence Flow-mediated dilation nationallicence Atherosclerosis nationallicence Yakut Mustafa Division of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey aut Üstün Yusuf Division of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey aut Kutlay Sim Division of Nephrology, Ibni Sina Hospital, Ankara University Medical School, Ankara, Turkey aut Ongun Aydan Department of Cardiology, Ibni Sina Hospital, Ankara University Medical School, Ankara, Turkey aut Kabaçam Gökhan Division of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey aut Boynueğri Recai Analiz Radiology Center, Ankara, Turkey aut Soykan Irfan Division of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3583-3589 0163-2116 56:12<3583 2011 56 10620 https://doi.org/10.1007/s10620-011-1778-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1778-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yakut Mustafa Division of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey aut NATIONALLICENCE 700 1- Üstün Yusuf Division of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey aut NATIONALLICENCE 700 1- Kutlay Sim Division of Nephrology, Ibni Sina Hospital, Ankara University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Ongun Aydan Department of Cardiology, Ibni Sina Hospital, Ankara University Medical School, Ankara, Turkey aut NATIONALLICENCE 700 1- Kabaçam Gökhan Division of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey aut NATIONALLICENCE 700 1- Boynueğri Recai Analiz Radiology Center, Ankara, Turkey aut NATIONALLICENCE 700 1- Soykan Irfan Division of Gastroenterology, Ibni Sina Hospital, Ankara University Medical School, 06100, Sihhiye, Ankara, Turkey aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3583-3589 0163-2116 56:12<3583 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer