caa a22 4500 445794844 CHVBK 20180317145121.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10620-011-1814-8 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1814-8 Smoking and the Association of Advanced Colorectal Neoplasia in an Asymptomatic Average Risk Population: Analysis of Exposure and Anatomical Location in Men and Women [Elektronische Daten] [Joseph Anderson, Koorosh Moezardalan, Catherine Messina, Michael Latreille, Robert Shaw] Background: Identifying risk factors for advanced colorectal adenomas may aid in colorectal cancer (CRC) screening, especially in light of the American College of Gastroenterology's recent guidelines, emphasizing cancer prevention through identification and removal of advanced adenomas. Smoking is an important risk factor for advanced adenomas but there is little data regarding levels of exposure for genders. Methods: The aim of this study was to use an existing database to examine the genders separately with respect to exposure level and anatomic location of advanced adenomas. Our database was designed to study smoking in an asymptomatic, screening population. Data included demographics, family history of CRC, smoking exposure (pack-years and years smoked), alcohol, diabetes, medications, exercise and dietary history. We excluded patients with a first degree relative with CRC. Results: Compared to non-smokers, female smokers had an increased risk for advanced adenomas with an exposure of 10-30 pack-years (adjusted odds ratio [AOR]=4.11; 95% confidence interval [CI], 1.88-9.01) as well as for ≥30 pack-years (AOR=2.54; 95% CI, 1.08-5.96) while men had an increased risk with smoking ≥30 pack-years (AOR=3.10; 95% CI, 1.71-5.65). An increased association with smoking was observed for proximal advanced adenomas (AOR=4.06; 95% CI, 1.62-10.19) and large hyperplastic polyps in women. Conclusions: Women smokers had an increased risk for advanced adenomas at a lower exposure level and had a greater risk for proximal lesions. These findings may have an impact on CRC screening for women. Springer Science+Business Media, LLC, 2011 Smoking nationallicence Sex nationallicence Adenoma nationallicence Colonoscopy and mass screening nationallicence Anderson Joseph Division of Gastroenterology and the Carole and Ray Neag Cancer Center, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, 06030-1845, Farmington, CT, USA aut Moezardalan Koorosh Division of Gastroenterology, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, 06030-1845, Farmington, CT, USA aut Messina Catherine Department of Preventive Medicine, Stony Brook University, Stony Brook, NY, USA aut Latreille Michael Department of Medicine, Columbia University, New York, NY, USA aut Shaw Robert Department of Medicine, Stony Brook University, Stony Brook, NY, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3616-3623 0163-2116 56:12<3616 2011 56 10620 https://doi.org/10.1007/s10620-011-1814-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1814-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Anderson Joseph Division of Gastroenterology and the Carole and Ray Neag Cancer Center, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, 06030-1845, Farmington, CT, USA aut NATIONALLICENCE 700 1- Moezardalan Koorosh Division of Gastroenterology, Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, 06030-1845, Farmington, CT, USA aut NATIONALLICENCE 700 1- Messina Catherine Department of Preventive Medicine, Stony Brook University, Stony Brook, NY, USA aut NATIONALLICENCE 700 1- Latreille Michael Department of Medicine, Columbia University, New York, NY, USA aut NATIONALLICENCE 700 1- Shaw Robert Department of Medicine, Stony Brook University, Stony Brook, NY, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/12(2011-12-01), 3616-3623 0163-2116 56:12<3616 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer