caa a22 4500 445794879 CHVBK 20180317145121.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1541-6 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1541-6 Is Obesity a Risk Factor for Crohn's Disease? [Elektronische Daten] [Michael Mendall, A. Viran Gunasekera, B. Joseph John, Devinder Kumar] Background: Obesity is associated with a proinflammatory state. Aim: To determine whether obesity at diagnosis is a risk factor for Crohn's disease vs. ulcerative colitis and also vs. community controls and whether there is a U-shaped relationship between body mass index at diagnosis and risk of Crohn's disease versus ulcerative colitis. Methods: A total of 524 consecutive inflammatory bowel disease patients attending gastroenterology clinics were administered a questionnaire inquiring about weight at diagnosis and height as well as other risk factors for inflammatory bowel disease. An opportunistic control group of 480 community controls aged 50-70 were randomly selected from the registers of four local general practices as part of another study. Results: Obesity at diagnosis was more common in subjects with Crohn's disease versus ulcerative colitis odds ratio 2.02 (1.18-3.43) p=0.0096 and also Crohn's disease versus community controls in the 50-70year age group (odds ratio 3.22 (1.59-6.52) p=0.001). There was evidence of a ‘dose response' with increasing degrees of obesity associated with increased risk. Low BMI at diagnosis was also associated with risk of Crohn's disease versus ulcerative colitis. A U-shaped relationship between BMI and risk of Crohn's was supported by the strong inverse association of BMI at diagnosis (p=0.0001) and positive association of BMI at diagnosis squared (p=0.0002) when they were fitted together into the model. Conclusions: Obesity may play a role in the pathogenesis of Crohn's disease and it may be that obesity-related enteropathy is a distinct entity or a sub-type of Crohn's disease. Springer Science+Business Media, LLC, 2011 Crohn's disease nationallicence Ulcerative colitis nationallicence Obesity nationallicence Environmental risk factors nationallicence Mesenteric fat nationallicence Mendall Michael Mayday University Hospital, Croydon, UK aut Viran Gunasekera A. Mayday University Hospital, Croydon, UK aut Joseph John B. Mayday University Hospital, Croydon, UK aut Kumar Devinder St. George's Medical School, London, UK aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 837-844 0163-2116 56:3<837 2011 56 10620 https://doi.org/10.1007/s10620-010-1541-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1541-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mendall Michael Mayday University Hospital, Croydon, UK aut NATIONALLICENCE 700 1- Viran Gunasekera A. Mayday University Hospital, Croydon, UK aut NATIONALLICENCE 700 1- Joseph John B. Mayday University Hospital, Croydon, UK aut NATIONALLICENCE 700 1- Kumar Devinder St. George's Medical School, London, UK aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 837-844 0163-2116 56:3<837 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer