caa a22 4500 445794909 CHVBK 20180317145121.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1330-2 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1330-2 The Use of a Patency Capsule in Pediatric Crohn's Disease: A Prospective Evaluation [Elektronische Daten] [Stanley Cohen, Ian Gralnek, Hagit Ephrath, Angela Stallworth, Tamara Wakhisi] Background: Capsule endoscopy (CE) retention remains a concern in patients with suspected or known Crohn's Disease (CD). Aim: The aim of this study was to evaluate the ability of a patency capsule (PC) to establish functional patency in pediatric patients with suspected or known, symptomatic IBD. Methods: A prospective, single center study evaluating the impact of CE on CD management used PC to qualify patients for CE. Patients excreting an intact PC, usually within 40h of ingestion, were able to undergo standard video CE. Excretion time, structural integrity and patient safety were evaluated. Results: Eighteen patients (10-16years of age; 9 male; 5 known CD, 3 indeterminate colitis, 1 ulcerative colitis, 9 suspected CD) ingested the PC. Fifteen patients excreted intact PC (mean 34.5h), 12 patients within 40h (range 9-60h). Sixteen (89%) underwent subsequent CE successfully. CD was eventually diagnosed in all patients having PC transit ≥40h, whereas CD was the diagnosis in 9/12 (75%) in those patients who passed the PC within 40 h. The mean time of passage for an intact PC was 34.7h, the longest 60h. There were no capsule retentions or adverse events. Conclusions: The PC appears to be a useful screening tool for functional patency of the small bowel in suspected or known pediatric CD. Delayed passage of an intact PC requires careful interpretation. Springer Science+Business Media, LLC, 2010 IBD nationallicence Crohn's disease nationallicence Pediatric IBD nationallicence Capsule endoscopy nationallicence Intestinal patency nationallicence Diagnostic tools nationallicence Small intestine nationallicence Cohen Stanley Children's Center for Digestive Health Care, Children's Healthcare of Atlanta, 993-D Johnson Ferry Road, Suite 440, 30342, Atlanta, GA, USA aut Gralnek Ian Rappaport Faculty of Medicine, GI Outcomes Unit, Department of Gastroenterology, Technion-Israel Institute of Technology, Rambam Health Care Campus, POB 9062, 31096, Haifa, Israel aut Ephrath Hagit Given Imaging Ltd., Hermon Building, P.O. Box 258, 20692, Yoqneam, Israel aut Stallworth Angela Children's Center for Digestive Health Care, Children's Healthcare of Atlanta, 993-D Johnson Ferry Road, Suite 440, 30342, Atlanta, GA, USA aut Wakhisi Tamara Children's Center for Digestive Health Care, Children's Healthcare of Atlanta, 993-D Johnson Ferry Road, Suite 440, 30342, Atlanta, GA, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 860-865 0163-2116 56:3<860 2011 56 10620 https://doi.org/10.1007/s10620-010-1330-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1330-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Cohen Stanley Children's Center for Digestive Health Care, Children's Healthcare of Atlanta, 993-D Johnson Ferry Road, Suite 440, 30342, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Gralnek Ian Rappaport Faculty of Medicine, GI Outcomes Unit, Department of Gastroenterology, Technion-Israel Institute of Technology, Rambam Health Care Campus, POB 9062, 31096, Haifa, Israel aut NATIONALLICENCE 700 1- Ephrath Hagit Given Imaging Ltd., Hermon Building, P.O. Box 258, 20692, Yoqneam, Israel aut NATIONALLICENCE 700 1- Stallworth Angela Children's Center for Digestive Health Care, Children's Healthcare of Atlanta, 993-D Johnson Ferry Road, Suite 440, 30342, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Wakhisi Tamara Children's Center for Digestive Health Care, Children's Healthcare of Atlanta, 993-D Johnson Ferry Road, Suite 440, 30342, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 860-865 0163-2116 56:3<860 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer