caa a22 4500 445794925 CHVBK 20180317145121.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1544-3 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1544-3 Vitamin D Deficiency in Children with Inflammatory Bowel Disease [Elektronische Daten] [Alon Levin, Veena Wadhera, Steven Leach, Helen Woodhead, Daniel Lemberg, A. Czarina Mendoza-Cruz, Andrew Day] Background: Osteopenia and osteoporosis are commonly seen in inflammatory bowel disease (IBD). Vitamin D deficiency potentially contributes to diminished bone acquisition in childhood. Objectives: The objectives of this study were to assess vitamin D in a group of Australian children with IBD and to ascertain associations between vitamin D status and key clinical factors, for example disease location and severity. Methods: Data were obtained retrospectively from the records of children with IBD who had at least one measurement of serum 25-hydroxyvitamin D (25(OH)D) over a two-year period. Demographic variables, disease activity, inflammatory markers, disease location, duration, and therapy were recorded. Moderate and severe deficiency were defined as 25(OH)D <51nmol/l and <30nmol/l, respectively. Insufficiency was defined as 25(OH)D between 51 and 75nmol/l. Results: Overall, the mean 25(OH)D level in 78 children (104 measurements) was 71.2 (SD±26.5) nmol/l. Fifteen (19%) children were vitamin D deficient and 30 (38%) children were insufficient. Levels of 25(OH)D were not associated with disease location or use of immunosuppressive drugs. Children with vitamin D deficiency had greater corticosteroid exposure than those with normal status (P=0.001). The mean 25(OH)D of 38 children treated with nutritional therapy at diagnosis was higher than for 17 children initially treated with corticosteroids (P=0.04). Conclusions: A high proportion of these Australian children with IBD were vitamin D deficient. This emphasizes the importance of monitoring vitamin D status, and treating deficiency, in the management of pediatric IBD. The possible benefit of nutritional therapy in protection against vitamin D deficiency requires further prospective study. Springer Science+Business Media, LLC, 2011 Inflammatory bowel disease nationallicence Crohn's disease nationallicence Children nationallicence Vitamin D deficiency nationallicence Corticosteroids nationallicence Exclusive enteral nutrition nationallicence Levin Alon School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut Wadhera Veena School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut Leach Steven School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut Woodhead Helen Department of Endocrinology, Sydney Children's Hospital, Randwick, Sydney, NSW, Australia aut Lemberg Daniel School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut Czarina Mendoza-Cruz A. Department of Endocrinology, Sydney Children's Hospital, Randwick, Sydney, NSW, Australia aut Day Andrew School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 830-836 0163-2116 56:3<830 2011 56 10620 https://doi.org/10.1007/s10620-010-1544-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1544-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Levin Alon School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Wadhera Veena School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Leach Steven School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Woodhead Helen Department of Endocrinology, Sydney Children's Hospital, Randwick, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Lemberg Daniel School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Czarina Mendoza-Cruz A. Department of Endocrinology, Sydney Children's Hospital, Randwick, Sydney, NSW, Australia aut NATIONALLICENCE 700 1- Day Andrew School of Women's & Children's Health, The University of New South Wales, Sydney, NSW, Australia aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 830-836 0163-2116 56:3<830 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer