caa a22 4500 445794968 CHVBK 20180317145121.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1343-x doi (NATIONALLICENCE)springer-10.1007/s10620-010-1343-x High Prevalence of Heartburn and Low Acid Sensitivity in Patients with Idiopathic Achalasia [Elektronische Daten] [Julio Ponce, Vicente Ortiz, Nuria Maroto, Marta Ponce, Marco Bustamante, Vicente Garrigues] Background: Heartburn is frequently reported by patients with achalasia before treatment. However, the esophageal sensitivity to acid as a possible mediator of this symptom has not been previously evaluated. Aim: To evaluate the prevalence of gastroesophageal reflux symptoms and the esophageal sensitivity to acid perfusion in patients with untreated achalasia. Methods: Forty patients with achalasia were prospectively evaluated. Forty-three patients with gastroesophageal reflux disease comprised the control group (ten of them with Barrett's esophagus). Symptoms were evaluated by a structured clinical questionnaire. Objective assessment was performed by ambulatory 24-h esophageal pH monitoring and endoscopy. Esophageal sensitivity to acid was evaluated by esophageal perfusion of ClH 0.1N. Results: Fifteen (37%) of the 40 patients with achalasia presented heartburn, but only four of them had esophagitis and/or abnormal esophageal pH recording. Eight patients had abnormal pH recording. Three patients had esophagitis. The esophagus was sensitive to acid in seven (17%) patients with achalasia, three of them with heartburn and one with abnormal pH recording. In the control group, 40 of 43 (93%) presented heartburn. Acid perfusion was positive in 32 (74%). Sensitivity to acid was lower in patients with achalasia than in those with gastroesophageal reflux disease with or without Barrett's esophagus. Conclusions: The prevalence of heartburn in patients with achalasia is high, although its association with objective indicators of gastroesophageal reflux disease is weak. Patients with achalasia have lower esophageal sensitivity to acid than patients with GERD, suggesting that heartburn is does not arise from this condition. Springer Science+Business Media, LLC, 2010 Achalasia nationallicence GERD nationallicence Heartburn nationallicence Sensitivity nationallicence Ponce Julio Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain aut Ortiz Vicente Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain aut Maroto Nuria Hospital de Manises, Valencia, Spain aut Ponce Marta Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain aut Bustamante Marco Hospital Dr Peset, Valencia, Spain aut Garrigues Vicente Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 773-776 0163-2116 56:3<773 2011 56 10620 https://doi.org/10.1007/s10620-010-1343-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1343-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ponce Julio Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain aut NATIONALLICENCE 700 1- Ortiz Vicente Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain aut NATIONALLICENCE 700 1- Maroto Nuria Hospital de Manises, Valencia, Spain aut NATIONALLICENCE 700 1- Ponce Marta Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain aut NATIONALLICENCE 700 1- Bustamante Marco Hospital Dr Peset, Valencia, Spain aut NATIONALLICENCE 700 1- Garrigues Vicente Gastroenterology Unit, Hospital Universitari La Fe, Valencia, Spain aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 773-776 0163-2116 56:3<773 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer