caa a22 4500 445794984 CHVBK 20180317145122.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1327-x doi (NATIONALLICENCE)springer-10.1007/s10620-010-1327-x Corticosteroids Modulate Angiogenic Soluble Factors in Ulcerative Colitis Patients [Elektronische Daten] [Inés Pousa, Alicia Algaba, Pablo Linares, Paloma Sanz-Cameno, José Maté, Ricardo Moreno-Otero, Fernando Bermejo, Javier Gisbert] Aims: The aim of this study was to compare angiogenic factors in serum levels of active ulcerative colitis (UC) patients and in healthy controls, and to analyze these angiogenic levels depending on the achievement of remission after oral corticosteroid treatment throughout treatment, and according to the Truelove-Witts activity index. Methods: Blood samples were collected from 13 patients receiving oral corticosteroids for treatment of UC flares at three different intervals—baseline, during, and after treatment—and from 26 healthy controls. Vascular endothelial growth factor (VEGF), placental growth factor (PlGF), VEGF receptor 1 (VEGFR1), angiopoietins (Ang) 1 and 2, and its receptor Tie2 were assayed by ELISA. Results: While VEGF and Ang2 levels in UC patients were higher than in healthy controls (P<0.05), UC patients showed lower levels of Ang1 than healthy individuals (P<0.05). In UC patients who achieved clinical remission after corticosteroid treatment, a statistically significant higher baseline serum level of PlGF was observed (22±5 vs. 18±2; P<0.05). Angiogenic factor levels varied during treatment; however, they did not show a statistically significant correlation to the activity of the disease. Conclusions: VEGF, Ang1, and Ang2 levels showed statistically significant differences between UC patients and healthy controls. Although determination of PlGF serum levels before corticosteroid treatment might be helpful to anticipate the response by UC patients, no angiogenic pattern that could accurately predict "a priori” this response to corticosteroid treatment was observed. Corticosteroids altered temporarily circulating levels of VEGF, angiopoietins and Tie2. No correlation was found between systemic levels of angiogenic factors and the clinical activity of UC. Springer Science+Business Media, LLC, 2010 Angiogenesis nationallicence Ulcerative colitis nationallicence Vascular endothelial growth factor nationallicence Angiogenic factors nationallicence UC : Ulcerative colitis nationallicence VEGF : Vascular endothelial growth factor nationallicence Ang : Angiopoietin nationallicence Tie2 : Angiopoietin receptor tirosin kinase nationallicence Pousa Inés Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut Algaba Alicia Department of Gastroenterology, Hospital Universitario de Fuenlabrada, Madrid, Spain aut Linares Pablo Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut Sanz-Cameno Paloma Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut Maté José Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut Moreno-Otero Ricardo Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut Bermejo Fernando Department of Gastroenterology, Hospital Universitario de Fuenlabrada, Madrid, Spain aut Gisbert Javier Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 871-879 0163-2116 56:3<871 2011 56 10620 https://doi.org/10.1007/s10620-010-1327-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1327-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pousa Inés Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut NATIONALLICENCE 700 1- Algaba Alicia Department of Gastroenterology, Hospital Universitario de Fuenlabrada, Madrid, Spain aut NATIONALLICENCE 700 1- Linares Pablo Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut NATIONALLICENCE 700 1- Sanz-Cameno Paloma Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut NATIONALLICENCE 700 1- Maté José Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut NATIONALLICENCE 700 1- Moreno-Otero Ricardo Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut NATIONALLICENCE 700 1- Bermejo Fernando Department of Gastroenterology, Hospital Universitario de Fuenlabrada, Madrid, Spain aut NATIONALLICENCE 700 1- Gisbert Javier Department of Gastroenterology, Hospital Universitario de La Princesa, Madrid, Spain aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 871-879 0163-2116 56:3<871 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer