caa a22 4500 445795034 CHVBK 20180317145122.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1352-9 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1352-9 p53 Status and Its Prognostic Role in Extrahepatic Bile Duct Cancer: A Meta-Analysis of Published Studies [Elektronische Daten] [Juan Wang, Xuefeng Wang, Shuyang Xie, Zhonghai Yan, Zunling Li, Youjie Li, Lei Wang, Fei Jiao] The dysfunction of p53 is the most common genetic alteration in human cancer. A variety of studies have investigated the clinicopathologic correlation of p53 and its impact on patient survival in different types of cancer. For extrahepatic bile duct cancer (EBDC), however, the results were limited and conflicting. In this study, we performed an investigation to confirm whether there was a correlation between p53 status and some routine parameters. To further observe the impact of p53 on the survival of EBDC patients, a meta-analysis based on published studies was conducted. Candidate studies were searched from PubMed, EMBASE, and ISI Web of Science. Our results demonstrated that there were significant correlations between p53 expression and some clinicopathological parameters. Furthermore, the pooled results of the meta-analysis showed that the combined hazard ratio (HR) estimate for overall survival (OS) was 1.53 (95% CI, 1.10-2.14) and 1.23 (95% CI, 0.93-1.75) in univariate and multivariate analysis, respectively. In conclusion, the high level of p53 appears to be an effective prognostic factor to OS of EBDC patients. However, some limitations unavoidable in this meta-analysis and problems of previous p53 studies in EBDC mean that further studies are necessary before significant conclusions can be made. Springer Science+Business Media, LLC, 2010 Extrahepatic bile duct cancer nationallicence p53 nationallicence Prognosis nationallicence Meta-analysis nationallicence Wang Juan Department of Biotechnology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut Wang Xuefeng Department of Hepatobiliary Surgery, Yuhuangding Hospital, 264000, Yantai, Shandong Province, People's Republic of China aut Xie Shuyang Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut Yan Zhonghai Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiao Tong University, 200040, Shanghai, People's Republic of China aut Li Zunling Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut Li Youjie Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut Wang Lei Department of Breast Surgery, Shandong Tumor Hospital, 250117, Ji'nan, Shandong Province, People's Republic of China aut Jiao Fei Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 655-662 0163-2116 56:3<655 2011 56 10620 https://doi.org/10.1007/s10620-010-1352-9 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1352-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wang Juan Department of Biotechnology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut NATIONALLICENCE 700 1- Wang Xuefeng Department of Hepatobiliary Surgery, Yuhuangding Hospital, 264000, Yantai, Shandong Province, People's Republic of China aut NATIONALLICENCE 700 1- Xie Shuyang Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut NATIONALLICENCE 700 1- Yan Zhonghai Shanghai Institute of Medical Genetics, Shanghai Children's Hospital, Shanghai Jiao Tong University, 200040, Shanghai, People's Republic of China aut NATIONALLICENCE 700 1- Li Zunling Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut NATIONALLICENCE 700 1- Li Youjie Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut NATIONALLICENCE 700 1- Wang Lei Department of Breast Surgery, Shandong Tumor Hospital, 250117, Ji'nan, Shandong Province, People's Republic of China aut NATIONALLICENCE 700 1- Jiao Fei Department of Biochemistry and Molecular Biology, Binzhou Medical College, 264003, Yantai, Shandong Province, People's Republic of China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 655-662 0163-2116 56:3<655 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer