caa a22 4500 445795093 CHVBK 20180317145122.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1328-9 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1328-9 Antiglycan Antibodies in Greek Patients with Inflammatory Bowel Disease [Elektronische Daten] [Ioannis Koutroubakis, Dimitrios Drygiannakis, Alexandra Tsirogianni, Pantelis Oustamanolakis, Konstantinos Karmiris, Konstantinos Papamichael, Gerassimos Mantzaris, Elias Kouroumalis] Background: Antiglycan antibodies have recently been reported to be associated with Crohn's disease (CD). These antibodies include anti-Saccharomyces cerevisiae mannan antibodies (ASCA), anti-laminariobioside carbohydrate antibodies (ALCA), anti-chitobioside carbohydrate antibodies (ACCA), and anti-mannobioside carbohydrate antibodies (AMCA). Aims: The aim of this study was to evaluate their diagnostic accuracy in Greek patients with inflammatory bowel disease (IBD). Methods: Serum was collected from 191 patients with IBD (85 with ulcerative colitis (UC) and 106 with CD), 29 cases with other causes of intestinal inflammation and 96 healthy controls. Antiglycan antibodies were measured using commercially available enzyme immunoassays. Results: Higher levels of antiglycan antibodies were detected in patients with CD compared to patients with UC and controls. Although all types of antiglycan antibodies had a high specificity for diagnosing CD, their sensitivity was rather low, with best results obtained with ASCA and ALCA (41.5 and 52.8%, respectively). Increased levels of ASCA and ALCA were associated with stricturing and penetrating disease phenotype, and the need for surgery (p<0.05). Conclusions: Antiglycan antibodies in Greek IBD patients are significantly associated with CD, and especially to phenotypes of complicated disease, with ASCA and ALCA exhibiting the highest sensitivity. Springer Science+Business Media, LLC, 2010 Anti- Saccharomyces cerevisiae antibodies nationallicence Crohn's disease nationallicence Serological markers nationallicence Ulcerative colitis nationallicence Koutroubakis Ioannis Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece aut Drygiannakis Dimitrios Laboratory of Immunology General Hospital of Rethymnon, Heraklion, Greece aut Tsirogianni Alexandra Department of Immunology-Histocompatibility, Evangelismos Hospital Athens, Athens, Greece aut Oustamanolakis Pantelis Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece aut Karmiris Konstantinos Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece aut Papamichael Konstantinos 1st Department of Gastroenterology, Evangelismos Hospital Athens, Athens, Greece aut Mantzaris Gerassimos 1st Department of Gastroenterology, Evangelismos Hospital Athens, Athens, Greece aut Kouroumalis Elias Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 845-852 0163-2116 56:3<845 2011 56 10620 https://doi.org/10.1007/s10620-010-1328-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1328-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Koutroubakis Ioannis Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Drygiannakis Dimitrios Laboratory of Immunology General Hospital of Rethymnon, Heraklion, Greece aut NATIONALLICENCE 700 1- Tsirogianni Alexandra Department of Immunology-Histocompatibility, Evangelismos Hospital Athens, Athens, Greece aut NATIONALLICENCE 700 1- Oustamanolakis Pantelis Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Karmiris Konstantinos Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece aut NATIONALLICENCE 700 1- Papamichael Konstantinos 1st Department of Gastroenterology, Evangelismos Hospital Athens, Athens, Greece aut NATIONALLICENCE 700 1- Mantzaris Gerassimos 1st Department of Gastroenterology, Evangelismos Hospital Athens, Athens, Greece aut NATIONALLICENCE 700 1- Kouroumalis Elias Department of Gastroenterology, University Hospital Heraklion, PO Box 1352, 71110, Heraklion, Crete, Greece aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 845-852 0163-2116 56:3<845 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer