caa a22 4500 445795123 CHVBK 20180317145122.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1371-6 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1371-6 Quantitative Assessment of Endoscopic Images for Degree of Villous Atrophy in Celiac Disease [Elektronische Daten] [Edward Ciaccio, Govind Bhagat, Christina Tennyson, Suzanne Lewis, Lincoln Hernandez, Peter Green] Background: The degree of villous atrophy in celiac disease is difficult to assess at endoscopy. We sought to develop a quantitative technique for the evaluation of villous atrophy in endoscopic images. Method: In ten celiac patients as identified by standard endoscopy with biopsy, and ten control patients, standard and videocapsule endoscopic images of the duodenum were digitized. Subimages 7.5×7.5mm2 in area from random locations within each image were assessed by measuring the length of mucosal fissures per unit area (L), and correlating L with the histologic grade of villous atrophy as determined by modified Marsh criteria. Results: Mean L values for standard endoscopic images were 37.8, 43.3, 64.1, and 83.5mm for Marsh grades II, IIIa, IIIb, and IIIc, respectively. Mean L values for videocapsule images were 49.1, 50.0, 64.7, and 72.4mm for Marsh grades II, IIIa, IIIb, and IIIc, respectively. Significant differences in the means existed between celiac images (Marsh scores II-IIIc) versus controls (p<0.001) for both endoscopic and videocapsule images. There were no significant differences between measurements obtained from endoscopic versus videocapsule images. Conclusions: Quantified image analysis correlates with the histologic grade of villous atrophy, is automated, and lacks observer bias, thus lending itself to standardization. Springer Science+Business Media, LLC, 2010 Celiac disease nationallicence Endoscopy nationallicence Videocapsule nationallicence Villous atrophy nationallicence Ciaccio Edward Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Bhagat Govind Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Tennyson Christina Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Lewis Suzanne Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Hernandez Lincoln Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Green Peter Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 805-811 0163-2116 56:3<805 2011 56 10620 https://doi.org/10.1007/s10620-010-1371-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1371-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ciaccio Edward Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Bhagat Govind Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Tennyson Christina Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Lewis Suzanne Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Hernandez Lincoln Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 700 1- Green Peter Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 805-811 0163-2116 56:3<805 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer