caa a22 4500 445795255 CHVBK 20180317145122.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1380-5 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1380-5 Bone Mineral Density, Vitamin D, and Disease Activity in Children Newly Diagnosed with Inflammatory Bowel Disease [Elektronische Daten] [Wael El-Matary, Sheena Sikora, Donald Spady] Background and Aim: The aim of this study was to examine bone mineral density and serum 25-hydroxy vitamin D in relation to disease activity in children newly diagnosed with IBD. Methods: In a cross-sectional analytic study, 60 children newly diagnosed with IBD (39 with Crohn's disease [CD], mean age 12.2±2.1years; and 21 with ulcerative colitis [UC], mean age 12.4±3.7years) were recruited. Fifty-six age- and sex-matched children without IBD were invited as controls (mean age 11.3±4.2years). Serum 25-hydroxy vitamin D for patients and controls was measured at diagnosis. Patients' adjusted lumbar spine bone mineral density (BMD) z scores were measured. Activity indices for both CD and UC were calculated. Results: The serum level of 25-hydroxy vitamin D was significantly lower in children with IBD compared to the control group (P=0.04). BMD was significantly lower in patients with CD compared to those with UC (P=0.039). There was no correlation between vitamin D levels, BMD z scores or disease activity indices for both CD and UC. Conclusions: Serum vitamin D level is significantly lower in children with newly diagnosed IBD compared to those without. However, vitamin D levels are not affected by disease severity. It seems that BMD status may not be affected by vitamin D levels or disease severity in this cohort. Larger prospective controlled studies are needed to confirm these findings. Springer Science+Business Media, LLC, 2010 IBD nationallicence Colitis nationallicence Vitamin D nationallicence Bone mineral density nationallicence El-Matary Wael Division of Pediatric Gastroenterology, Alder Hey Children's NHS Foundation Trust, Eaton Road, L12 2AP, Liverpool, UK aut Sikora Sheena Division of Pediatric Gastroenterology, Hepatology and Nutrition, Stollery Children's Hospital, Edmonton, Alberta, Canada aut Spady Donald Division of Pediatric Epidemiology, University of Alberta, Edmonton, Alberta, Canada aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 825-829 0163-2116 56:3<825 2011 56 10620 https://doi.org/10.1007/s10620-010-1380-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1380-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- El-Matary Wael Division of Pediatric Gastroenterology, Alder Hey Children's NHS Foundation Trust, Eaton Road, L12 2AP, Liverpool, UK aut NATIONALLICENCE 700 1- Sikora Sheena Division of Pediatric Gastroenterology, Hepatology and Nutrition, Stollery Children's Hospital, Edmonton, Alberta, Canada aut NATIONALLICENCE 700 1- Spady Donald Division of Pediatric Epidemiology, University of Alberta, Edmonton, Alberta, Canada aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 825-829 0163-2116 56:3<825 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer