caa a22 4500 44579528X CHVBK 20180317145122.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1341-z doi (NATIONALLICENCE)springer-10.1007/s10620-010-1341-z Helicobacter pylori Induces Expression and Secretion of Oncostatin M in Macrophages In Vitro [Elektronische Daten] [Zaher Zeaiter, Hugo Diaz, Markus Stein, Hien Huynh] Background: Helicobacter pylori is pathogenic bacterium that is associated with several gastric diseases in humans. Disease is characterized by severe inflammatory responses is the stomach that are induced by various chemokines and cytokines. Previous reports indicated that some of these responses are mediated through Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling. Methods: We performed JAK/STAT specific microarrays to identify new components of this signaling pathway, which are affected by Helicobacter pylori infection of THP-1 cells. Results: We found that expression and secretion of oncostatin M and of its receptor were strongly up-regulated by Helicobacter pylori. OSM secretion was independent of CagA, VacA or Type IV secretion system. Helicobacter pylori culture supernatant induced OSM secretion. Conclusion: The induction of the pleiotropic cytokine oncostatin M suggests a possible role in Helicobacter pylori-mediated inflammation and diseases. Springer Science+Business Media, LLC, 2010 Helicobacter pylori nationallicence Oncostatin M nationallicence IL-6 nationallicence STAT/JAK signaling nationallicence Zeaiter Zaher Department of Medical Microbiology and Immunology, University of Alberta, T6G2H7, Edmonton, AB, Canada aut Diaz Hugo Department of Medical Microbiology and Immunology, University of Alberta, T6G2H7, Edmonton, AB, Canada aut Stein Markus Department of Medical Microbiology and Immunology, University of Alberta, T6G2H7, Edmonton, AB, Canada aut Huynh Hien Department of Pediatrics, University of Alberta, 11402 University Ave., T6G 2J3, Edmonton, AB, Canada aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 689-697 0163-2116 56:3<689 2011 56 10620 https://doi.org/10.1007/s10620-010-1341-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1341-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zeaiter Zaher Department of Medical Microbiology and Immunology, University of Alberta, T6G2H7, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Diaz Hugo Department of Medical Microbiology and Immunology, University of Alberta, T6G2H7, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Stein Markus Department of Medical Microbiology and Immunology, University of Alberta, T6G2H7, Edmonton, AB, Canada aut NATIONALLICENCE 700 1- Huynh Hien Department of Pediatrics, University of Alberta, 11402 University Ave., T6G 2J3, Edmonton, AB, Canada aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 689-697 0163-2116 56:3<689 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer