caa a22 4500 445795298 CHVBK 20180317145123.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s10620-010-1326-y doi (NATIONALLICENCE)springer-10.1007/s10620-010-1326-y Anti-Alpha-Enolase Antibody as a Serologic Marker and Its Correlation with Disease Severity in Intestinal Behçet's Disease [Elektronische Daten] [Sung Shin, Byung Kim, Tae Kim, Sang Lee, Kwang Lee, Won Kim] Background: Intestinal Behçet's disease (BD) is a chronic inflammatory bowel disease, as are Crohn's disease (CD) and ulcerative colitis (UC). But unlike CD and UC, serologic markers for intestinal BD are not well known. Recently, anti-α-enolase antibody (AAEA) has been detected in sera from BD patients. Aims: The aim of this study was to evaluate the prevalence of AAEA in intestinal BD and its clinical correlations. Methods: The study sample included 80 patients with intestinal BD and 23 healthy controls. IgM AAEA was detected by ELISA. The positivity of IgM AAEA was defined as an optical density greater than three standard deviations above the mean of the control sera. Other parameters, such as demographic information, subtype of BD, colonoscopic findings, disease severity and treatment modality, were analyzed retrospectively. Results: The prevalence of IgM AAEA was 67.5% in intestinal BD and 0% in the control group. The positivity rate of IgM AAEA was higher in complete or incomplete BD than in suspected BD (77.5% vs. 51.6%, P=0.016). The mean HBI score was higher in antibody positive patients than in antibody negative patients (5.60 vs. 4.61, P=0.003). The cumulative probability of steroid use for aggravation of intestinal and extra-intestinal symptoms was higher in antibody positive patients than in antibody negative patients (P=0.012). The number of patients with systemic involvement was higher in the AAEA positive group than in the negative group. Conclusions: Monitoring IgM AAEA may be helpful for diagnosis of intestinal BD and could be used to predict clinical course and disease severity. Springer Science+Business Media, LLC, 2010 Anti-α-enolase antibody nationallicence Disease severity nationallicence Intestinal Behçet's disease nationallicence Serologic marker nationallicence Shin Sung Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut Kim Byung Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut Kim Tae Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut Lee Sang Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut Lee Kwang Department of Dermatology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut Kim Won Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 812-818 0163-2116 56:3<812 2011 56 10620 https://doi.org/10.1007/s10620-010-1326-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1326-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shin Sung Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Byung Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Tae Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Sang Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Kwang Department of Dermatology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Won Department of Internal Medicine, Institute of Gastroenterology, Yonsei University College of Medicine, 134 Shinchon-Dong Seodaemun-ku, 120-752, Seoul, Korea aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/3(2011-03-01), 812-818 0163-2116 56:3<812 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer