caa a22 4500 445795395 CHVBK 20180317145123.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10620-011-1772-1 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1772-1 Efficacy and Tolerability of Split-Dose PEG Compared with Split-Dose Aqueous Sodium Phosphate for Outpatient Colonoscopy: A Randomized, Controlled Trial [Elektronische Daten] [Eun Seo, Tae Kim, Tae Kim, Hee Joo, Min Park, Jongha Park, Seung Park, Sung Yang, Young Moon] Background and Aims: Adequate bowel cleansing is essential for a high-quality, effective, and safe colonoscopy. The aims of this study were to compare the efficacy and tolerability of split-dose polyethylene glycol with aqueous sodium phosphate for outpatients who underwent scheduled colonoscopy. Methods: In this prospective trial, 207 outpatients (aged between 18 and 65years, with normal renal function, at low risk for renal damage) were randomized to receive split-dose preparation of PEG (2 L/2 L) (N=103) or NaP (45mL/45mL, 12h apart) (N=104) without strict diet restriction the day before colonoscopy. The bowel cleansing efficacy of preparations was rated according to the Ottawa scale and the patient tolerability was assessed using a patient questionnaire. Results: There was no significant difference between the two groups for the mean total score using the Ottawa bowel preparation scale (P=0.181). Significantly greater residual colonic fluid was observed in the split-dose PEG group (1.24±0.49) than in the NaP group (1.04±0.53) (P=0.007). Patient compliance, preference, and acceptance of a two preparation regimen were similar with no significant differences (P=0.095, P=0.280 and P=0.408, respectively). The overall incidence of adverse events was not significantly different between the two groups; however, the split-dose PEG group tended to have fewer adverse events (52/103 [50.5%], 66/104 [63.5%], P=0.059) and had significantly less nausea and vomiting (P=0.036). Conclusions: Split-dose PEG, compared with split-dose NaP, is associated with more residual colonic fluid, but produces equivalent colon cleansing efficacy and results in less nausea and vomiting, which might improve patient tolerability (clinical trial registration number NCT01229800). The Author(s), 2011 Colonoscopy nationallicence Bowel preparation nationallicence Polyethylene glycols nationallicence Sodium phosphate nationallicence Seo Eun Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut Kim Tae Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut Joo Hee Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut Park Min Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut Park Jongha Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut Park Seung Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut Yang Sung Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut Moon Young Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 2963-2971 0163-2116 56:10<2963 2011 56 10620 https://doi.org/10.1007/s10620-011-1772-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1772-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Seo Eun Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut NATIONALLICENCE 700 1- Kim Tae Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut NATIONALLICENCE 700 1- Joo Hee Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut NATIONALLICENCE 700 1- Park Min Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut NATIONALLICENCE 700 1- Park Jongha Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut NATIONALLICENCE 700 1- Park Seung Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut NATIONALLICENCE 700 1- Yang Sung Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut NATIONALLICENCE 700 1- Moon Young Department of Internal Medicine, Haeundae Paik Hospital, Inje University School of Medicine, 1435 Jwa-dong, 612-030, Haeundae-gu, Busan, Republic of Korea aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 2963-2971 0163-2116 56:10<2963 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer