caa a22 4500 445795492 CHVBK 20180317145123.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10620-011-1670-6 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1670-6 Acoustic Liver Biopsy in Patients with Hepatitis C and Advanced Liver Fibrosis Using Endoscopic Ultrasound [Elektronische Daten] [Anil Vegesna, Amer Nazir, Chan Chung, Saul Kane, Rebecca Thomas, Larry Miller] Background: Transabdominal ultrasound cannot be used to quantitate fibrosis in patients with advanced liver fibrosis due to variability in the abdominal wall thickness and composition. This variability can be eliminated by using endoscopic ultrasound. Aim: The purpose of this study was to determine the amount of fibrosis in the liver of hepatitis C patients with advanced fibrosis using endoscopic ultrasound. Methods: Endoscopic ultrasound images of the liver were recorded by keeping the gain, contrast, frequency, magnification and acoustic power constant on the ultrasound processor. Videotaped images of the liver were digitized on Image-Pro Plus software. Using adobe Photoshop, a histogram was produced to quantitate the luminosity of the five areas of interest per image. Quantification of the ultrasound images were done by two independent investigators blinded to the Ishak liver fibrosis score. The mean luminosity of the ultrasound images were compared with the Ishak fibrosis score. The study was performed in seven patients (mean age 54years; 3 male, 4 female) with hepatitis C and advanced liver fibrosis. Results: The correlation between the two independent investigators for the ultrasound images was 0.93. The correlation between the mean luminosity on ultrasound images to the Ishak fibrosis score was r=0.77, r=0.72 and r=0.73 for the most hyperechoic area of interest, total hyperechoic area and for the entire liver, respectively. Conclusion: A new technique was developed that uses endoscopic ultrasound to evaluate the degree of fibrosis in patients with advanced liver fibrosis. There is a good correlation between the luminosity on endoscopic ultrasound and the Ishak fibrosis score. Springer Science+Business Media, LLC, 2011 Acoustic liver biopsy nationallicence Endoscopic ultrasound nationallicence Cirrhosis nationallicence Hepatitis C nationallicence Staging of liver fibrosis nationallicence Luminosity nationallicence Vegesna Anil Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut Nazir Amer Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut Chung Chan Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut Kane Saul Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut Thomas Rebecca Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut Miller Larry Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 3053-3057 0163-2116 56:10<3053 2011 56 10620 https://doi.org/10.1007/s10620-011-1670-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1670-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vegesna Anil Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Nazir Amer Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Chung Chan Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Kane Saul Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Thomas Rebecca Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 700 1- Miller Larry Department of Medicine, Section of Gastroenterology, Temple University Hospital, 8th Floor Parkinson Pavillion, 19140, Philadelphia, PA, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 3053-3057 0163-2116 56:10<3053 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer