caa a22 4500 445795514 CHVBK 20180317145123.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10620-011-1696-9 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1696-9 Expression of IFN-γ and IL-4 in the Esophageal Mucosa of Patients with Reflux Esophagitis and Barrett's Esophagus and Their Relationship with Endoscopic and Histologic Grading [Elektronische Daten] [Ying-Qiang Zhong, Ying Lin, Zhe Xu] Introduction: This study investigated the expression of interferon-γ (IFN-γ) and interleukin-4 (IL-4) in the esophageal biopsies from patients with reflux esophagitis (RE) and Barrett's esophagus (BE) and their relationships with endoscopic grading and histologic grading. Methods: Ninety individuals were recruited (30 RE, 30 BE, and 30 normal control) and underwent upper gastrointestinal endoscopy with esophageal biopsy. Immunohistochemistry was used to semi-quantitatively detect the expression of IFN-γ and IL-4 in the specimens. Results: IFN-γ was overexpressed in BE and RE compared with the control (P<0.01), whereas IL-4 was up-regulated in BE compared with RE and control (P<0.01). A positive correlation between the level of IFN-γ and the endoscopic grading (r=0.509, P<0.01) and histologic grading of RE (r=0.493, P<0.01) was observed. Conclusions: Th1 and Th2 immune responses play different roles in the development of RE and BE. Th1 immune response is the major pathway for RE development, whereas both Th1 and Th2 immune responses are implicated in BE pathogenesis. The expression of IFN-γ is associated with the endoscopic and histologic grading of RE. Springer Science+Business Media, LLC, 2011 Reflux esophagitis nationallicence Barrett's esophagus nationallicence IFN-γ nationallicence IL-4 nationallicence Endoscopy nationallicence Histology nationallicence Zhong Ying-Qiang Department of Gastroenterology and Hepatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 West Yanjiang Road, 510120, Guangzhou, China aut Lin Ying Department of Gastroenterology and Hepatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 West Yanjiang Road, 510120, Guangzhou, China aut Xu Zhe Department of Gastroenterology and Hepatology, Dongguan People's Hospital, Dongguan, China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 2865-2870 0163-2116 56:10<2865 2011 56 10620 https://doi.org/10.1007/s10620-011-1696-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1696-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhong Ying-Qiang Department of Gastroenterology and Hepatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 West Yanjiang Road, 510120, Guangzhou, China aut NATIONALLICENCE 700 1- Lin Ying Department of Gastroenterology and Hepatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 West Yanjiang Road, 510120, Guangzhou, China aut NATIONALLICENCE 700 1- Xu Zhe Department of Gastroenterology and Hepatology, Dongguan People's Hospital, Dongguan, China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 2865-2870 0163-2116 56:10<2865 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer