caa a22 4500 445795565 CHVBK 20180317145123.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10620-011-1712-0 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1712-0 Plasma Free Myristic Acid Proportion Is a Predictor of Nonalcoholic Steatohepatitis [Elektronische Daten] [Kengo Tomita, Toshiaki Teratani, Hirokazu Yokoyama, Takahiro Suzuki, Rie Irie, Hirotoshi Ebinuma, Hidetsugu Saito, Ryota Hokari, Soichiro Miura, Toshifumi Hibi] Background/Aims: Serum free fatty acid (FFA) composition and abnormal fatty acid metabolism have been implicated in the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, we determined if the serum FFA composition can provide accurate diagnosis of NASH. Methods: We compared fasting serum FFA compositions in 20 patients with simple steatosis to those in 77 patients with NASH, including 65 patients with early-stage NASH. Results: By univariate analysis, the proportions of serum free myristic acid (P=0.002) and palmitoleic acid (P=0.033) and the stearoyl CoA desaturase (SCD)-1 index (P=0.047) were significantly elevated in NASH patients in comparison to patients with simple steatosis. Only the serum free myristic acid proportion was significantly elevated in the early-stage NASH group in comparison to the simple steatosis group (P=0.003). Multiple logistic regression analysis demonstrated that the serum free myristic acid proportion was significantly elevated in all patients with NASH (P=0.011) and the subset of patients with early-stage NASH (P=0.012) in comparison to those with simple steatosis. The area under the curve (AUC) for the serum free myristic acid proportion was 0.734 to detect NASH and 0.719 to detect early-stage NASH in comparison to simple steatosis. Conclusions: Serum free myristic acid proportion could be a useful independent predictor to differentiate NASH from simple steatosis. Springer Science+Business Media, LLC, 2011 Diagnosis nationallicence Free fatty acid nationallicence Myristic acid nationallicence Nonalcoholic fatty liver disease nationallicence Nonalcoholic steatohepatitis nationallicence NAFLD : Nonalcoholic fatty liver disease nationallicence NASH : Nonalcoholic steatohepatitis nationallicence SFA : Saturated fatty acid nationallicence FFA : Free fatty acid nationallicence MUFA : Monounsaturated fatty acid nationallicence PUFA : Polyunsaturated fatty acid nationallicence SCD : Stearoyl-CoA desaturase nationallicence SD : Standard deviation nationallicence ANOVA : Analysis of variance nationallicence ROC : Receiver operating characteristic nationallicence BMI : Body mass index nationallicence HOMA-IR : Homeostasis model assessment for insulin resistance nationallicence IRI : Immunoreactive insulin nationallicence AUC : Area under the curve nationallicence PPV : Positive predictive value nationallicence NPV : Negative predictive value nationallicence TLR4 : Toll-like receptor 4 nationallicence Tomita Kengo Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut Teratani Toshiaki Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut Yokoyama Hirokazu Health Center, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut Suzuki Takahiro Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut Irie Rie Department of Pathology, Kawasaki Municipal Hospital, 12-1 Shinkawadori, 210-0013, Kawasaki-ku, Kawasaki-shi, Kanagawa, Japan aut Ebinuma Hirotoshi Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut Saito Hidetsugu Graduate School of Pharmaceutical Sciences, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, 105-8512, Minato-ku, Tokyo, Japan aut Hokari Ryota Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa-shi, Saitama, Japan aut Miura Soichiro Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa-shi, Saitama, Japan aut Hibi Toshifumi Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 3045-3052 0163-2116 56:10<3045 2011 56 10620 https://doi.org/10.1007/s10620-011-1712-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1712-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tomita Kengo Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Teratani Toshiaki Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Yokoyama Hirokazu Health Center, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Suzuki Takahiro Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Irie Rie Department of Pathology, Kawasaki Municipal Hospital, 12-1 Shinkawadori, 210-0013, Kawasaki-ku, Kawasaki-shi, Kanagawa, Japan aut NATIONALLICENCE 700 1- Ebinuma Hirotoshi Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Saito Hidetsugu Graduate School of Pharmaceutical Sciences, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, 105-8512, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Hokari Ryota Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa-shi, Saitama, Japan aut NATIONALLICENCE 700 1- Miura Soichiro Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa-shi, Saitama, Japan aut NATIONALLICENCE 700 1- Hibi Toshifumi Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, 160-8582, Shinjuku-ku, Tokyo, Japan aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 3045-3052 0163-2116 56:10<3045 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer