caa a22 4500 445795603 CHVBK 20180317145124.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10620-011-1687-x doi (NATIONALLICENCE)springer-10.1007/s10620-011-1687-x Small HCCs Identified by Screening [Elektronische Daten] [Petr Pancoska, Massimo De Giorgio, Stefano Fagiuoli, Brian Carr] Background: Survival in HCC depends on diagnosis at early tumor stage, best achieved through surveillance radiology. There is also a need for complementary serum tests. Methods: We evaluated baseline liver function parameters from a cohort of 231 HCC patients who were diagnosed by surveillance. They were ordered according to their tumor mass and trends in the data were analyzed. Results: Trends in serum GGTP levels increased linearly with increases in small tumor mass, but the patterns for AFP levels were more complex and elevated only with larger tumor mass. ALKP levels were elevated in association with small tumors and further increased with increasing tumor mass. The relationships of serum AFP to GGTP, of albumin to bilirubin and of ALKP to bilirubin, helped identify tumor mass phenotypes. There was an especially important relationship between serum bilirubin and AFP, suggesting that HCC growth and liver factors were interdependent. Conclusions: Small HCCs demonstrated several phenotypic sub-groups, with serum GGTP and ALKP increasing and albumin decreasing in many patients with increasing tumor mass. Springer Science+Business Media, LLC, 2011 HCC nationallicence Small tumors nationallicence GGTP nationallicence ALKP nationallicence Tumor mass nationallicence Surveillance nationallicence HCC : Hepatocellular carcinoma nationallicence AFP : Alpha-fetoprotein nationallicence TBili : Total bilirubin nationallicence GGTP : Gamma glutamyl transpeptidase nationallicence ALKP : Alkaline phosphatase nationallicence CT : Computerized axial tomography scan nationallicence Pancoska Petr Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA aut De Giorgio Massimo Division of Gastroenterology, Ospedali Riuniti, Bergamo, Italy aut Fagiuoli Stefano Division of Gastroenterology, Ospedali Riuniti, Bergamo, Italy aut Carr Brian Department of Nutrition and Exptl Biology, IRCCS Saverio de Bellis Medical Research Institute, Via F. Valente 4, 70013, Castellana Grotte, Bari, Italy aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 3078-3085 0163-2116 56:10<3078 2011 56 10620 https://doi.org/10.1007/s10620-011-1687-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1687-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pancoska Petr Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- De Giorgio Massimo Division of Gastroenterology, Ospedali Riuniti, Bergamo, Italy aut NATIONALLICENCE 700 1- Fagiuoli Stefano Division of Gastroenterology, Ospedali Riuniti, Bergamo, Italy aut NATIONALLICENCE 700 1- Carr Brian Department of Nutrition and Exptl Biology, IRCCS Saverio de Bellis Medical Research Institute, Via F. Valente 4, 70013, Castellana Grotte, Bari, Italy aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 3078-3085 0163-2116 56:10<3078 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer