caa a22 4500 445795778 CHVBK 20180317145124.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10620-011-1751-6 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1751-6 Generalized Transit Delay on Wireless Motility Capsule Testing in Patients with Clinical Suspicion of Gastroparesis, Small Intestinal Dysmotility, or Slow Transit Constipation [Elektronische Daten] [Braden Kuo, Monthira Maneerattanaporn, Allen Lee, Jason Baker, Stephen Wiener, William Chey, Gregory Wilding, William Hasler] Background: The prevalence of generalized transit delay and relation to symptoms in suspected gastroparesis, intestinal dysmotility, or slow transit constipation are unknown. Aims: The aims of this study were (1) to define prevalence of generalized dysmotility using wireless motility capsules (WMC), (2) to relate to symptoms in suspected regional delay, (3) to compare results of WMC testing to conventional transit studies to quantify new diagnoses, and (4) to assess the impact of results of WMC testing on clinical decisions. Methods: WMC transits were analyzed in 83 patients with suspected gastroparesis, intestinal dysmotility, or slow transit constipation. Results: Isolated regional delays were observed in 32% (9% stomach, 5% small bowel, 18% colon). Transits were normal in 32% and showed generalized delays in 35%. Symptom profiles were similar with normal transit, isolated delayed gastric, small intestinal, and colonic transit, and generalized delay (P=NS). Compared to conventional tests, WMC showed discordance in 38% and provided new diagnoses in 53%. WMC testing influenced management in 67% (new medications 60%; modified nutritional regimens 14%; surgical referrals 6%) and eliminated needs for testing not already done including gastric scintigraphy (17%), small bowel barium transit (54%), and radioopaque colon marker tests (68%). Conclusions: WMC testing defines localized and generalized transit delays with suspected gastroparesis, intestinal dysmotility, or slow transit constipation. Symptoms do not predict the results of WMC testing. WMC findings provide new diagnoses in >50%, may be discordant with conventional tests, and can influence management by changing treatments and eliminating needs for other tests. These findings suggest potential benefits of this method in suspected dysmotility syndromes and mandate prospective investigation to further define its clinical role. Springer Science+Business Media, LLC, 2011 Gastric emptying nationallicence Colonic transit nationallicence Nausea and vomiting nationallicence Constipation nationallicence Intestinal pseudoobstruction nationallicence Kuo Braden Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA aut Maneerattanaporn Monthira Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, 48109, Ann Arbor, MI, USA aut Lee Allen Division of Gastroenterology, Tufts Medical Center, Boston, MA, USA aut Baker Jason Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, 48109, Ann Arbor, MI, USA aut Wiener Stephen Center for Digestive Care, Pentucket Medical, Haverhill, MA, USA aut Chey William Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, 48109, Ann Arbor, MI, USA aut Wilding Gregory Department of Statistics, State University of New York at Buffalo, Buffalo, NY, USA aut Hasler William Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, 48109, Ann Arbor, MI, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 2928-2938 0163-2116 56:10<2928 2011 56 10620 https://doi.org/10.1007/s10620-011-1751-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1751-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuo Braden Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA aut NATIONALLICENCE 700 1- Maneerattanaporn Monthira Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Lee Allen Division of Gastroenterology, Tufts Medical Center, Boston, MA, USA aut NATIONALLICENCE 700 1- Baker Jason Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Wiener Stephen Center for Digestive Care, Pentucket Medical, Haverhill, MA, USA aut NATIONALLICENCE 700 1- Chey William Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 700 1- Wilding Gregory Department of Statistics, State University of New York at Buffalo, Buffalo, NY, USA aut NATIONALLICENCE 700 1- Hasler William Division of Gastroenterology, University of Michigan Health System, 3912 Taubman Center, 5362, 48109, Ann Arbor, MI, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/10(2011-10-01), 2928-2938 0163-2116 56:10<2928 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer