caa a22 4500 445795786 CHVBK 20180317145124.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1456-2 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1456-2 Daily Ciprofloxacin Treatment for Patients with Advanced Liver Disease Awaiting Liver Transplantation Reduces Hospitalizations [Elektronische Daten] [G. Minuk, K. Hawkins, K. Kaita, S. Wong, E. Renner, L. Minuk, J. Uhanova] Background: Progressive deterioration in liver function is a common cause of hepatic decompensation and indication for liver transplantation in patients with advanced liver disease. Previous studies in animal models of acute and chronic liver disease revealed that daily ciprofloxacin improves biochemical parameters of hepatic function. Aims: The primary objective of this study was to determine whether hepatic function improves in patients with advanced liver disease after 1month of daily ciprofloxacin therapy. A secondary objective was to determine whether ciprofloxacin treatment for 1 or 3months results in fewer hospitalizations for decompensated liver disease. Methods: Forty-four patients with advanced liver disease awaiting liver transplantation received oral ciprofloxacin (250 or 500mg twice daily) or placebo for 1 (n=22/group) or 3 (n=10 ciprofloxacin, 14 placebo) months. Results: Compared to placebo recipients, ciprofloxacin-treated patients had mild improvements in serum albumin levels (+1.5 versus −3.4%, p=0.026) while bilirubin and international normalized ratios (INR) of prothrombin times remained unchanged. Overall, fewer hospitalizations occurred in ciprofloxacin-treated patients (1/22, 5% versus 7/22, 32%, respectively, p=0.02) during the study period. Treatment was well tolerated and no resistant infections occurred in either cohort. Conclusions: The results of this study suggest that daily ciprofloxacin may result in fewer hospitalizations for patients with advanced liver diseases awaiting liver transplantation but not by enhancing hepatic function. Springer Science+Business Media, LLC, 2010 Decompensated cirrhosis nationallicence Fluoroquinolones nationallicence Ciprofloxacin nationallicence Hepatic encephalopathy nationallicence Portal hypertension nationallicence Liver function nationallicence Minuk G. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut Hawkins K. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut Kaita K. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut Wong S. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut Renner E. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut Minuk L. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut Uhanova J. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1235-1241 0163-2116 56:4<1235 2011 56 10620 https://doi.org/10.1007/s10620-010-1456-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1456-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Minuk G. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Hawkins K. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Kaita K. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Wong S. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Renner E. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Minuk L. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 700 1- Uhanova J. Section of Hepatology, Department of Medicine, University of Manitoba, 803F John Buhler Research Centre, 715 McDermot Avenue, R3E 3P4, Winnipeg, Manitoba, Canada aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1235-1241 0163-2116 56:4<1235 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer