caa a22 4500 445795794 CHVBK 20180317145124.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1417-9 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1417-9 Prevalence and Impact of Hepatic Steatosis on the Response to Antiviral Therapy in Saudi Patients with Genotypes 1 and 4 Chronic Hepatitis C [Elektronische Daten] [Abdallah AlQaraawi, Faisal Sanai, Hussa Al-Husseini, Ali Albenmousa, Abdulmalik AlSheikh, Lubna Ahmed, Ahmad Hersi, Molfi Al-Otaibi, Mohammed Syed, Safiyya Ali, Waleed Al-hamoudi, Khalid Alswat, Ayman Abdo] Background: Hepatic steatosis in hepatitis C virus (HCV)-infected patients has been shown to enhance the progression of liver fibrosis and decrease the response to antiviral therapy. Aims: We aimed to determine the role of HCV genotype 4 (HCV-G4) in the prevalence of hepatic steatosis, its impact on antiviral therapy, and its associations and predictive factors in comparison to HCV-G1-infected patients. Methods: Treatment-naïve HCV patients who were started on pegylated interferon a-2b plus ribavirin therapy in two centers in Saudi Arabia were included. The severity of steatosis was assessed using the METAVIR and NAS (non-alcoholic fatty liver disease [NAFLD] activity score) scoring systems. Sustained virological response (SVR) was studied in relation to the degree of steatosis. Associations between steatosis and multiple demographic, laboratory, and virological factors were examined. HCV-G1 and HCV-G4 patients were compared. Results: A total of 116 patients (HCV-G4 85 [73.3%]; HCV-G1 31 [26.7%]) were included. The mean age was 50.4±10.7years and 56.9% were males. In terms of steatosis grading using the NAS scoring system, 50% had steatosis grade 0, 26.7% grade 1, 14.7% grade 2, and 8.6% grade 3, while the overall staging of steatosis revealed that 43.1% had mild steatosis, 42.2% moderate, and 14.7% severe. Gamma-glutamyl transpeptidase (GGT), platelet count, body mass index (BMI), cholesterol level, presence of hyperlipidemia, liver histology stage, and grade were significantly correlated with hepatic steatosis in one or more of the statistical analyses. Twenty-two out of 55 patients (40.0%) had an SVR in the mild steatosis group, compared to 52.7% in the moderate group and 7.3% in the severe group (P=0.03). The HCV genotype did not correlate with steatosis or SVR. Conclusion: Our study confirms the high prevalence of steatosis in HCV-G4 and HCV-G1 patients, but with no difference in the grade or score of steatosis between the two genotypes. The grade of steatosis correlates with GGT, platelet count, and BMI, while the NAS score of steatosis correlates with response to antiviral therapy. Springer Science+Business Media, LLC, 2010 Hepatitis C nationallicence Steatosis nationallicence Histology nationallicence Genotype 4 nationallicence NAS score nationallicence Inflammation nationallicence Fibrosis nationallicence Interferon nationallicence AlQaraawi Abdallah Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut Sanai Faisal Department of Hepatobiliary Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia aut Al-Husseini Hussa Department of Pathology, Riyadh Military Hospital, Riyadh, Saudi Arabia aut Albenmousa Ali Hepatology Unit, Department of Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia aut AlSheikh Abdulmalik Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia aut Ahmed Lubna Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia aut Hersi Ahmad Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut Al-Otaibi Molfi Hepatology Unit, Department of Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia aut Syed Mohammed Hepatology Unit, Department of Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia aut Ali Safiyya Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia aut Al-hamoudi Waleed Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut Alswat Khalid Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut Abdo Ayman Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1222-1228 0163-2116 56:4<1222 2011 56 10620 https://doi.org/10.1007/s10620-010-1417-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1417-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- AlQaraawi Abdallah Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Sanai Faisal Department of Hepatobiliary Sciences, King Abdulaziz Medical City, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Al-Husseini Hussa Department of Pathology, Riyadh Military Hospital, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Albenmousa Ali Hepatology Unit, Department of Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- AlSheikh Abdulmalik Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Ahmed Lubna Department of Pathology, College of Medicine, King Saud University, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Hersi Ahmad Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Al-Otaibi Molfi Hepatology Unit, Department of Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Syed Mohammed Hepatology Unit, Department of Medicine, Riyadh Military Hospital, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Ali Safiyya Liver Disease Research Center, King Saud University, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Al-hamoudi Waleed Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Alswat Khalid Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut NATIONALLICENCE 700 1- Abdo Ayman Department of Medicine, College of Medicine, King Saud University, P.O. Box 2925 (59), 11461, Riyadh, Saudi Arabia aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1222-1228 0163-2116 56:4<1222 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer