caa a22 4500 445795824 CHVBK 20180317145124.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1389-9 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1389-9 The Expression of Both Peroxisome Proliferator-Activated Receptor Delta and Cyclooxygenase-2 in Tissues Is Associated with Poor Prognosis in Colorectal Cancer Patients [Elektronische Daten] [Masahiro Yoshinaga, Kentaro Taki, Shinichi Somada, Yumiko Sakiyama, Norihiko Kubo, Toyoma Kaku, Satoru Tsuruta, Tetsuya Kusumoto, Hironori Sakai, Kazuhiko Nakamura, Ryoichi Takayanagi, Yoichi Muto] Background: The role of peroxisome proliferator-activated receptor delta (PPAR δ) in the development and progression of colorectal cancer (CRC) remains controversial. Aims: We investigated the impact of PPAR δ expression in tissues on liver metastasis of CRC. Methods: We analyzed samples of primary CRC and matched normal adjacent tissues from 52 patients for the expression of PPAR δ, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF)-A, and CXC chemokine receptor 4 (CXCR4). Correlations of the molecules expressions with clinical characteristics and prognosis of patients were studied. Results: The number of patients positive for PPAR δ, COX-2, CXCR4, and VEGF-A was 25, 33, 18, and 19, respectively. Among the PPAR δ (+)/COX-2 (+), PPAR δ (−)/COX-2 (+), PPAR δ (+)/COX-2 (−), and PPAR δ (−)/COX-2 (−) patient groups, PPAR δ (+)/COX-2 (+) patients had the highest incidence of liver metastasis (p<0.01). PPAR δ (+)/COX-2 (+) expression was a significant independent prognostic factor (HR=7.108, 95% CI 1.231-41.029, p=0.0283) by Cox proportional analysis. PPAR δ (+)/COX-2 (+) patients had the highest positivity for CXCR4 or VEGF-A in tissues (p<0.01). Among the patients in the CXCR4 (+)/VEGF-A (+), CXCR4 (+)/VEGF-A (−), CXCR4 (−)/VEGF-A (+), and CXCR4 (−)/VEGF-A (−) groups, CXCR4 (+)/VEGF-A (+) patients had the highest incidence of liver metastasis (p<0.01). Conclusions: The expression of both PPAR δ and COX-2 in tissues may lead to liver metastasis and consequent poor prognosis in CRC patients. Springer Science+Business Media, LLC, 2010 Peroxisome proliferator-activated receptor delta nationallicence Cyclooxygenase-2 nationallicence Colorectal cancer nationallicence CXC chemokine receptor 4 nationallicence Liver metastasis nationallicence Yoshinaga Masahiro Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut Taki Kentaro Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut Somada Shinichi Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut Sakiyama Yumiko Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut Kubo Norihiko Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut Kaku Toyoma Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut Tsuruta Satoru Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut Kusumoto Tetsuya Department of Clinical Research, National Hospital Organization Beppu Medical Center, Oita, Japan aut Sakai Hironori Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut Nakamura Kazuhiko Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Takayanagi Ryoichi Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut Muto Yoichi Department of Surgery, National Hospital Organization Beppu Medical Center, Oita, Japan aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1194-1200 0163-2116 56:4<1194 2011 56 10620 https://doi.org/10.1007/s10620-010-1389-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1389-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshinaga Masahiro Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Taki Kentaro Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Somada Shinichi Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Sakiyama Yumiko Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Kubo Norihiko Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Kaku Toyoma Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Tsuruta Satoru Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Kusumoto Tetsuya Department of Clinical Research, National Hospital Organization Beppu Medical Center, Oita, Japan aut NATIONALLICENCE 700 1- Sakai Hironori Department of Gastroenterology, Hepatology, and Nutrition, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, 874-0011, Beppu, Oita, Japan aut NATIONALLICENCE 700 1- Nakamura Kazuhiko Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Takayanagi Ryoichi Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan aut NATIONALLICENCE 700 1- Muto Yoichi Department of Surgery, National Hospital Organization Beppu Medical Center, Oita, Japan aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1194-1200 0163-2116 56:4<1194 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer