caa a22 4500 445795875 CHVBK 20180317145125.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1531-8 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1531-8 Endoscopic Diagnosis of Open-Type Atrophic Gastritis Is Related to the Histological Diagnosis of Intestinal Metaplasia and Cdx2 Expression [Elektronische Daten] [Su Ahn, Sun-Young Lee, Sung Hong, Jeong Kim, In-Kyung Sung, Hyung Park, Chan Shim, Choon Jin, Hye Han] Background and Objectives: Long-term Helicobacter pylori infection results in atrophic gastritis and intestinal metaplasia (IM) with Cdx2 expression. We have tried to determine if there was a link between endoscopic and histological diagnosis of IM based on the status of aberrant Cdx2 expression. Methods: One hundred and one subjects agreed to upper gastrointestinal endoscopic examination, with biopsy sampling for histology, Giemsa, and Cdx2 immunohistochemical staining before and after the treatment. On endoscopic examination, atrophic gastritis was defined as discoloration with blood vessel transparency, and was classified as either closed or open. Metaplastic gastritis was defined by the presence of whitish patches, whitish plaques, and/or homogeneous whitish discoloration. Histologic analysis was performed to determine H. pylori density, intensity of acute polymorphonuclear cell infiltrates and chronic mononuclear infiltrates, gastric atrophy, and IM as demonstrated using immunohistochemistry for cdx2. Results: Cdx2 protein expression (P=0.018) and the prevalence of histologically detected IM (P=0.011) were higher in cases of endoscopically diagnosed open-type atrophic gastritis and metaplastic gastritis than in closed-type atrophic gastritis and nonatrophic/nonmetaplastic cases. The degree of activity (P=0.006) and inflammation (P=0.007) improved significantly after four weeks of successful H. pylori eradication treatment, whereas the degree of atrophy, metaplasia, and Cdx2 expression did not. Conclusions: Unlike endoscopic diagnosis of closed-type atrophic gastritis, that of open-type atrophic gastritis is highly correlated with the histological diagnosis of IM and Cdx2 expression. Endoscopically diagnosed open-type atrophic gastritis and endoscopically diagnosed metaplastic gastritis have similar histological features, which suggests that a high percentage of IM cases are diagnosed as open-type atrophic gastritis by endoscopic examination. Springer Science+Business Media, LLC, 2011 Cdx2 nationallicence Intestinal metaplasia nationallicence Atrophic gastritis nationallicence Helicobacter pylori nationallicence Ahn Su Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut Lee Sun-Young Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut Hong Sung Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut Kim Jeong Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut Sung In-Kyung Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut Park Hyung Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut Shim Chan Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut Jin Choon Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut Han Hye Department of Pathology, Konkuk University School of Medicine, Seoul, Korea aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1119-1126 0163-2116 56:4<1119 2011 56 10620 https://doi.org/10.1007/s10620-010-1531-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1531-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ahn Su Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut NATIONALLICENCE 700 1- Lee Sun-Young Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut NATIONALLICENCE 700 1- Hong Sung Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut NATIONALLICENCE 700 1- Kim Jeong Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut NATIONALLICENCE 700 1- Sung In-Kyung Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut NATIONALLICENCE 700 1- Park Hyung Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut NATIONALLICENCE 700 1- Shim Chan Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut NATIONALLICENCE 700 1- Jin Choon Department of Internal Medicine, Konkuk University School of Medicine, 4-12 Hwayang-dong, Gwangjin-gu, 143-729, Seoul, South Korea aut NATIONALLICENCE 700 1- Han Hye Department of Pathology, Konkuk University School of Medicine, Seoul, Korea aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1119-1126 0163-2116 56:4<1119 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer