caa a22 4500 445795980 CHVBK 20180317145125.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1393-0 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1393-0 Pioglitazone: A Promising Therapeutic Tool in Sodium Taurocholate-Induced Severe Acute Pancreatitis [Elektronische Daten] [Ping Xu, Kai Xu, Jing Wang, Jin-Ping Jiang, Ling-Quan Chen] Background: Studies suggest that peroxisome proliferator-activated receptor γ(PPARγ) ligands may represent a therapeutic option in acute pancreatitis, yet most of them have been prophylactic administrated. Aims: To evaluate the therapeutic effect of pioglitazone in rats with severe acute pancreatitis induced by sodium taurocholate. Methods: Severe acute pancreatitis (SAP) was induced in male Sprague-Dawley rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. After SAP was induced, pioglitazone was injected intraperitoneally and its role on the severity of inflammatory response and pancreatic injury was investigated. Amylase activity, inflammatory cytokines production, pathological changes of pancreas, PPARγ mRNA expression, and the survival rate were examined. Results: Treatment with pioglitazone decreased the level of amylase activity, proinflammatory factors IL-6 and TNF-α, ameliorated pancreatic histological score, and upregulated the expression of PPARγ mRNA. The survival rate in the early stage of severe acute pancreatitis was also improved. Conclusions: Pioglitazone can be used as a therapeutic drug and relieve the damages caused by SAP, which suggests PPARγ ligand-pioglitazone offers a potent approach for the treatment of severe acute pancreatitis. Springer Science+Business Media, LLC, 2010 Severe acute pancreatitis nationallicence Sodium taurocholate nationallicence Peroxisome proliferator-activated receptor-γ ligand nationallicence Pioglitazone nationallicence Xu Ping Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut Xu Kai Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut Wang Jing Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut Jiang Jin-Ping Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut Chen Ling-Quan Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1082-1089 0163-2116 56:4<1082 2011 56 10620 https://doi.org/10.1007/s10620-010-1393-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1393-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xu Ping Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut NATIONALLICENCE 700 1- Xu Kai Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut NATIONALLICENCE 700 1- Wang Jing Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut NATIONALLICENCE 700 1- Jiang Jin-Ping Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut NATIONALLICENCE 700 1- Chen Ling-Quan Department of Gastroenterology, Bronch Hospital of the First People's Hospital, Shanghai Jiao Tong University, School of Medicine, 201600, Shanghai, China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1082-1089 0163-2116 56:4<1082 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer