caa a22 4500 445795999 CHVBK 20180317145125.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1406-z doi (NATIONALLICENCE)springer-10.1007/s10620-010-1406-z Lung Diffusion Capacity in Early Cirrhosis: Is Lung Diffusion Capacity a Predictor of Esophageal Varices and Ascites? [Elektronische Daten] [Jun Jung, Dae Jun, Jae Lee] Background: Varices and ascites are clinical manifestations of hyperdynamic circulation syndrome originating from increased nitric oxide in cirrhosis. Research was conducted in order to find any correlation between lung diffusion capacity and the presence of varices and ascites in cirrhosis. Methods: The study was conducted on a total of 120 subjects. Tests for pulmonary function, including carbon monoxide diffusing capacity (DLCO) and fractional exhaled nitric oxide (FENO), were performed. Results: DLCO/alveolar ventilation (VA) values were lower in cirrhosis and chronic liver disease groups than in the control group (3.79 vs. 4.5 vs. 5.1ml/mmHg/min, p<0.001). DLCO/VA showed a negative correlation with the Child score and the MELD score (r=−0.3 vs. r=−0.41). In patients with varices, the DLCO/VA value was 3.75ml/mmHg/min, which was lower than the 4.12ml/mmHg/min observed in patients without varices (p=0.029). FENO levels were higher in the chronic liver disease and liver cirrhosis groups than in the control group. FENO and DLCO showed a negative correlation (r=−0.25, p=0.006). The frequency of significant varix and decompensation were higher in the high FeNO group. Conclusions: Lung diffusion capacity decreased according to the disease's severity in early cirrhosis, and showed a good correlation with esophageal varices and ascites. Springer Science+Business Media, LLC, 2010 Nitric oxide nationallicence Pulmonary diffusing capacity nationallicence Liver cirrhosis nationallicence Esophageal and gastric varices nationallicence Jung Jun Department of Internal Medicine, Eulji University School of Medicine, Eulji Hospital, Seoul, Korea aut Jun Dae Department of Internal Medicine, College of Medicine, Hanyang University School of Medicine, Hanyang University Hospital, 17 Haengdang-dong, Sungdong-ku, 133-791, Seoul, Korea aut Lee Jae Department of Internal Medicine, Eulji University School of Medicine, Eulji Hospital, Seoul, Korea aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1229-1234 0163-2116 56:4<1229 2011 56 10620 https://doi.org/10.1007/s10620-010-1406-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1406-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jung Jun Department of Internal Medicine, Eulji University School of Medicine, Eulji Hospital, Seoul, Korea aut NATIONALLICENCE 700 1- Jun Dae Department of Internal Medicine, College of Medicine, Hanyang University School of Medicine, Hanyang University Hospital, 17 Haengdang-dong, Sungdong-ku, 133-791, Seoul, Korea aut NATIONALLICENCE 700 1- Lee Jae Department of Internal Medicine, Eulji University School of Medicine, Eulji Hospital, Seoul, Korea aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1229-1234 0163-2116 56:4<1229 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer