caa a22 4500 445796014 CHVBK 20180317145125.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1560-3 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1560-3 Adverse Effects of Long-Term Proton Pump Inhibitor Therapy [Elektronische Daten] [Edward Sheen, George Triadafilopoulos] Proton pump inhibitors have an excellent safety profile and have become one of the most commonly prescribed class of drugs in primary and specialty care. Long-term, sometimes lifetime, use is becoming increasingly common, often without appropriate indications. This paper is a detailed review of the current evidence on this important topic, focusing on the potential adverse effects of long-term proton pump inhibitor use that have generated the greatest concern: B12 deficiency; iron deficiency; hypomagnesemia; increased susceptibility to pneumonia, enteric infections, and fractures; hypergastrinemia and cancer; drug interactions; and birth defects. We explain the pathophysiological mechanisms that may underlie each of these relationships, review the existing evidence, and discuss implications for clinical management. The benefits of proton pump inhibitor use outweigh its risks in most patients. Elderly, malnourished, immune-compromised, chronically ill, and osteoporotic patients theoretically could be at increased risk from long-term therapy. Springer Science+Business Media, LLC, 2011 Proton pump inhibitors nationallicence Safety nationallicence Adverse effects nationallicence Malabsorption nationallicence Fractures nationallicence Infections nationallicence Cancer nationallicence Interactions nationallicence Sheen Edward Department of Medicine and Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 94305, Stanford, CA, USA aut Triadafilopoulos George Department of Medicine and Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 94305, Stanford, CA, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 931-950 0163-2116 56:4<931 2011 56 10620 https://doi.org/10.1007/s10620-010-1560-3 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1560-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sheen Edward Department of Medicine and Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 94305, Stanford, CA, USA aut NATIONALLICENCE 700 1- Triadafilopoulos George Department of Medicine and Division of Gastroenterology and Hepatology, Stanford University School of Medicine, 94305, Stanford, CA, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 931-950 0163-2116 56:4<931 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer