caa a22 4500 445796030 CHVBK 20180317145125.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1383-2 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1383-2 Adult Patients with Eosinophilic Esophagitis Do Not Show an Increased Frequency of the HLA-DQ2/DQ8 Genotypes Predisposing to Celiac Disease [Elektronische Daten] [Alfredo Lucendo, Ángel Arias, Isabel Pérez-Martínez, Antonio López-Vázquez, Jesús Ontañón-Rodríguez, Sonia González-Castillo, Livia De Rezende, Luis Rodrigo] Background: Recent articles have described patients that share eosinophilic esophagitis (EoE) and celiac disease (CD) suggesting a true relationship between both diseases. Aims: The purpose of this study was to investigate whether HLA DQ2 and DQ8 predisposing to CD are increased in adult patients with EoE. Methods: HLA alleles conferring risk for CD was assessed in 75 adult EoE patients attended at two hospitals located in different Spanish regions over the past 2years. We compared the frequencies to the registered data of 421 healthy kidney and bone marrow donors from our hospitals for the following alleles: (a) DR3-DQ2 haplotype; (b) the combination of DR3-DQ2 and DR4-DQ8; (c) DR4-DQ8 haplotype; (d) the simultaneous presence of the DR5-DQ7 and DR7-DQ2 haplotypes; and lastly (e) any combination of haplotypes not conferring risk for the development of CD. Results: The HLA DQ2 and DQ8 alleles were analyzed in 58 adult EoE patients from hospital #1 and in 20 patients from hospital #2, and they were compared to recorded HLA genotyping data from 298 and 123 healthy donors, respectively. No differences were found between the distribution of the HLA frequencies of the patients and controls at both hospitals and the data could be combined. EoE patients did not show increased frequencies of DQ2 and DQ8 alleles compared to controls. Conclusions: Our work does not allow us to establish a common genetic basis for EoE and CD because an increased frequency of the HLA DQ2 and DQ8 alleles predisposing to CD was not observed in adult EoE patients compared to controls. Springer Science+Business Media, LLC, 2010 Eosinophilic esophagitis nationallicence Celiac disease nationallicence HLA antigens nationallicence DQ2 genotype nationallicence DQ8 genotype nationallicence Lucendo Alfredo Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, s/n, 13700, Tomelloso, Ciudad Real, Spain aut Arias Ángel Research Unit, Complejo Hospitalario La Mancha Centro, Alcázar de San Juan, Spain aut Pérez-Martínez Isabel Department of Gastroenterology, Hospital Central de Asturias, Oviedo, Spain aut López-Vázquez Antonio Department of Immunology, Hospital Central de Asturias, Oviedo, Spain aut Ontañón-Rodríguez Jesús Department of Immunology, Hospital General Universitario de Albacete, Albacete, Spain aut González-Castillo Sonia Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, s/n, 13700, Tomelloso, Ciudad Real, Spain aut De Rezende Livia Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, s/n, 13700, Tomelloso, Ciudad Real, Spain aut Rodrigo Luis Department of Gastroenterology, Hospital Central de Asturias, Oviedo, Spain aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1107-1111 0163-2116 56:4<1107 2011 56 10620 https://doi.org/10.1007/s10620-010-1383-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1383-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lucendo Alfredo Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, s/n, 13700, Tomelloso, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Arias Ángel Research Unit, Complejo Hospitalario La Mancha Centro, Alcázar de San Juan, Spain aut NATIONALLICENCE 700 1- Pérez-Martínez Isabel Department of Gastroenterology, Hospital Central de Asturias, Oviedo, Spain aut NATIONALLICENCE 700 1- López-Vázquez Antonio Department of Immunology, Hospital Central de Asturias, Oviedo, Spain aut NATIONALLICENCE 700 1- Ontañón-Rodríguez Jesús Department of Immunology, Hospital General Universitario de Albacete, Albacete, Spain aut NATIONALLICENCE 700 1- González-Castillo Sonia Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, s/n, 13700, Tomelloso, Ciudad Real, Spain aut NATIONALLICENCE 700 1- De Rezende Livia Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, s/n, 13700, Tomelloso, Ciudad Real, Spain aut NATIONALLICENCE 700 1- Rodrigo Luis Department of Gastroenterology, Hospital Central de Asturias, Oviedo, Spain aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1107-1111 0163-2116 56:4<1107 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer