caa a22 4500 445796111 CHVBK 20180317145125.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1416-x doi (NATIONALLICENCE)springer-10.1007/s10620-010-1416-x Expression and Prognostic Significance of CD151, c-Met, and Integrin alpha3/alpha6 in Pancreatic Ductal Adenocarcinoma [Elektronische Daten] [Guang-Hui Zhu, Chen Huang, Zheng-Jun Qiu, Jun Liu, Zhi-Hua Zhang, Ning Zhao, Zheng-Zhong Feng, Xiu-Hong Lv] Background: CD151, c-Met, and integrin alpha3/alpha6 are all involved in the hepatocyte growth factor (HGF)/c-Met signal pathway, which plays an important role in the malignant progression of tumors. Aims: The purpose of this study was to explore the expression and prognostic significance of these proteins in pancreatic ductal adenocarcinoma (PDAC). Methods: We used immunohistochemical methods to investigate the expression patterns of CD151, c-Met, and integrin alpha3/alpha6proteins in 71 patients with PDAC and in ten samples of normal pancreatic tissue. We also assessed correlations between these proteins and clinicopathological parameters and survival of PDAC patients using various statistical methods. Results: CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in PDAC. CD151 and c-Met overexpressions were significantly associated with TNM stage (p=0.001 and p=0.038, respectively) and lymph node invasion (p=0.000, p=0.012, respectively). A significant positive linear correlation was found between CD151 and c-Met (r=0.583; p=0.000), integrin alpha3 (r=0.457; p=0.000), and integrin alpha6 (r=0.671; p=0.000). Overexpression of CD151, c-Met, integrin alpha3, or integrin alpha6 was related to poor survival of PDAC patients (p=0.000, p=0.000, p=0.005, and p=0.003, respectively), and CD151 and c-Met were independent factors in prognosis of PDAC. Conclusions: CD151, c-Met, and integrin alpha3/alpha6 were all overexpressed in PDAC. CD151 and c-Met might be new molecular markers to predict the prognosis of PDAC patients. Springer Science+Business Media, LLC, 2010 CD151 nationallicence c-Met nationallicence Integrin alpha3 nationallicence Integrin alpha6 nationallicence Pancreatic ductal adenocarcinoma nationallicence Prognosis nationallicence Zhu Guang-Hui Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut Huang Chen Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut Qiu Zheng-Jun Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut Liu Jun Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut Zhang Zhi-Hua Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut Zhao Ning Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut Feng Zheng-Zhong Department of Clinical Pathology, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut Lv Xiu-Hong Department of Clinical Pathology, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1090-1098 0163-2116 56:4<1090 2011 56 10620 https://doi.org/10.1007/s10620-010-1416-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1416-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhu Guang-Hui Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut NATIONALLICENCE 700 1- Huang Chen Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut NATIONALLICENCE 700 1- Qiu Zheng-Jun Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut NATIONALLICENCE 700 1- Liu Jun Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut NATIONALLICENCE 700 1- Zhang Zhi-Hua Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut NATIONALLICENCE 700 1- Zhao Ning Department of General Surgery, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut NATIONALLICENCE 700 1- Feng Zheng-Zhong Department of Clinical Pathology, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut NATIONALLICENCE 700 1- Lv Xiu-Hong Department of Clinical Pathology, Affiliated First People's Hospital, Shanghai Jiao Tong University, 200080, Shanghai, China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 1090-1098 0163-2116 56:4<1090 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer