caa a22 4500 445796189 CHVBK 20180317145126.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s10620-010-1404-1 doi (NATIONALLICENCE)springer-10.1007/s10620-010-1404-1 Unusual Case of Small Cell Gastric Carcinoma: Case Report and Literature Review [Elektronische Daten] [David Richards, Daniel Davis, Peisha Yan, Sushovan Guha] Background: Small cell carcinomas are among the most aggressive, poorly differentiated, and highly malignant of the neuroendocrine tumors (NETs). Of which, small cell gastric carcinoma is a rare small cell neuroendocrine tumor. The purpose of our study was to present this case and perform a comprehensive literature review. Methods and Results: We review a case of small cell gastric carcinoma that is particularly unusual in that it occurred in a woman from the US when the majority of cases of small cell gastric carcinoma have been reported in men from East Asia, and more specifically, from Japan. The diagnosis was made after endoscopy revealed a large ulcerated mass in the gastric cardia of Borrmann type 3. Biopsies revealed multiple small basophilic cells underlying the squamous epithelium of the esophagus and cardiac mucosa, indicating the presence of a tumor at the gastroesophageal junction. Immunostaining established the diagnosis with positive stains for chromogranin, synaptophysin, and CD56. Our patient is being treated with chemotherapy, but many different treatment regimens have been tried for small cell gastric carcinoma with variable success. Conclusions: Overall prognosis for small cell gastric carcinoma is dismal. Neuroendocrine tumors in general have variable clinical behaviors and prognosis is dependent on the neuroendocrine tumor type. The adoption of a standardized classification system for neuroendocrine tumors could improve the recognition of infrequently encountered neuroendocrine tumors like small cell gastric carcinoma and will enhance strategies for treatment and thus improve prognosis for patients with these rare and aggressive tumors. Springer Science+Business Media, LLC, 2010 Neuroendocrine tumors nationallicence Small cell gastric carcinoma nationallicence Carcinoid nationallicence Small cell lung carcinoma nationallicence Richards David Department of Internal Medicine, Division of Gastroenterology, Hepatology, and Nutrition, The University of Texas Health Science Center at Houston, Houston, TX, USA aut Davis Daniel Department of Pathology, The University of Texas Health Science Center at Houston, Houston, TX, USA aut Yan Peisha Department of Pathology, The University of Texas Health Science Center at Houston, Houston, TX, USA aut Guha Sushovan Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit Number 1466, 77030, Houston, TX, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 951-957 0163-2116 56:4<951 2011 56 10620 https://doi.org/10.1007/s10620-010-1404-1 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-010-1404-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Richards David Department of Internal Medicine, Division of Gastroenterology, Hepatology, and Nutrition, The University of Texas Health Science Center at Houston, Houston, TX, USA aut NATIONALLICENCE 700 1- Davis Daniel Department of Pathology, The University of Texas Health Science Center at Houston, Houston, TX, USA aut NATIONALLICENCE 700 1- Yan Peisha Department of Pathology, The University of Texas Health Science Center at Houston, Houston, TX, USA aut NATIONALLICENCE 700 1- Guha Sushovan Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit Number 1466, 77030, Houston, TX, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/4(2011-04-01), 951-957 0163-2116 56:4<951 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer