caa a22 4500 445796227 CHVBK 20180317145126.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1632-z doi (NATIONALLICENCE)springer-10.1007/s10620-011-1632-z Is Inflammatory Bowel Disease an Important Risk Factor Among Older Persons with Colorectal Cancer in the United States? A Population-Based Case-Control Study [Elektronische Daten] [Aasma Shaukat, Daniel Virnig, Nadim Salfiti, David Howard, Shanthi Sitaraman, Jonathan Liff] Background: While ulcerative colitis (UC) and Crohn's disease (CD) are thought to predispose to colorectal cancer (CRC), the association has not been well studied in an older population. Aims: The objective of our study was to evaluate the association of ulcerative colitis and Crohn's disease and colorectal cancer in a population-based, case-control study. We also wished to estimate the incidence rates of colorectal cancer among older individuals with UC/CD. Methods: All cases of colorectal cancer in persons 67 and older in the SEER catchment area and in the Medicare claims database were compared with cancer-free controls residing in the same geographic area. We used multivariable logistic regression models adjusted for demographic and other factors. Results: We identified 47,543 cases of CRC and 142,273 controls. We found a modest association between UC and CRC (OR 1.93; 95% CI 1.54-2.49; P-value<0.001) and a significant, albeit modest, association between CD and CRC (OR 1.45; 95% CI 1.08-1.91; P-value 0.01). We found the incidence of CRC to be 8.2 per 10,000 person-years (95% CI 6.5-10.1/10,000 person-years) among those with UC/CD, and 6.1 per 10,000 person-years (95% CI 4.6-7.8/10,000 person-years) among those without UC/CD, resulting in an incidence rate ratio of 1.34. Conclusions: Among older persons ulcerative colitis and Crohn's disease are modest risk factors for CRC, and the incidence rate ratio for CRC is modest, suggesting that risk of CRC in patients with IBD may be lower than previously thought. Springer Science+Business Media, LLC, 2011 Ulcerative colitis nationallicence Colorectal cancer nationallicence Shaukat Aasma Section of Gastroenterology, Department of Medicine, VA Medical Center and University of Minnesota, Gastroenterology Section111-D, 1- Veterans Drive, 55417, Minneapolis, MN, USA aut Virnig Daniel Section of Gastroenterology, Department of Medicine, VA Medical Center and University of Minnesota, Gastroenterology Section111-D, 1- Veterans Drive, 55417, Minneapolis, MN, USA aut Salfiti Nadim Section of Gastroenterology, Department of Medicine, VA Medical Center and University of Minnesota, Gastroenterology Section111-D, 1- Veterans Drive, 55417, Minneapolis, MN, USA aut Howard David Department of Health, Policy & Management, Rollins School of Public Health, Emory University, Atlanta, GA, USA aut Sitaraman Shanthi Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA aut Liff Jonathan Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2378-2383 0163-2116 56:8<2378 2011 56 10620 https://doi.org/10.1007/s10620-011-1632-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1632-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shaukat Aasma Section of Gastroenterology, Department of Medicine, VA Medical Center and University of Minnesota, Gastroenterology Section111-D, 1- Veterans Drive, 55417, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Virnig Daniel Section of Gastroenterology, Department of Medicine, VA Medical Center and University of Minnesota, Gastroenterology Section111-D, 1- Veterans Drive, 55417, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Salfiti Nadim Section of Gastroenterology, Department of Medicine, VA Medical Center and University of Minnesota, Gastroenterology Section111-D, 1- Veterans Drive, 55417, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Howard David Department of Health, Policy & Management, Rollins School of Public Health, Emory University, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Sitaraman Shanthi Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA, USA aut NATIONALLICENCE 700 1- Liff Jonathan Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2378-2383 0163-2116 56:8<2378 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer