caa a22 4500 445796243 CHVBK 20180317145126.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1633-y doi (NATIONALLICENCE)springer-10.1007/s10620-011-1633-y Fecal Calprotectin Is a Useful Marker for Disease Activity in Pediatric Patients with Inflammatory Bowel Disease [Elektronische Daten] [Tomoki Aomatsu, Atsushi Yoden, Kyoichi Matsumoto, Emi Kimura, Keisuke Inoue, Akira Andoh, Hiroshi Tamai] Background: Studies evaluating the correlation between endoscopic disease activity and noninvasive markers are scarce in inflammatory bowel disease (IBD). Aim: The aim of this study is to evaluate the accuracy of the fecal calprotectin (FC) assay as a marker of disease activity of IBD, as determined by an extensive endoscopic scoring system. Methods: Thirty-five children and adolescents with IBD [17 with ulcerative colitis (UC) and 18 with Crohn's disease (CD)] and 28 healthy volunteers were enrolled. FC levels were determined by ELISA. The sum of Matts' score for UC and the simple endoscopic score for Crohn's disease (SES-CD) were used. The ileal lesions were evaluated by ultrasonography. Results: In UC patients, there was a strong correlation between FC levels and the sum of Matts' score (r=0.838, p<0.01). FC levels were significantly elevated in endoscopically active patients (median 1,562.5μg/g) as compared to patients in endoscopic remission (median 38.9μg/g) or healthy controls (median 19.9μg/g). In CD patients, there was a strong correlation between FC levels and the SES-CD score (r=0.760, p < 0.01). The FC levels were significantly higher in endoscopically active patients (median 2,037.5μg/g) than in endoscopically inactive patients (median 172.5μg/g) or healthy controls (median 19.9μg/g), respectively. The FC levels of patients with ileal wall thickening (median 2,225.0μg/g) were significantly higher than healthy controls (median 19.9μg/g) and patients lacking ileal wall thickening (median 17.5μg/g), respectively. Conclusions: The FC assay is a useful marker for the detection of mucosal inflammation in pediatric IBD patients. Springer Science+Business Media, LLC, 2011 Fecal calprotectin nationallicence Inflammatory bowel disease nationallicence Children nationallicence Mucosal healing nationallicence Biomarker nationallicence Aomatsu Tomoki Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, 569-8686, Takatsuki, Japan aut Yoden Atsushi Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, 569-8686, Takatsuki, Japan aut Matsumoto Kyoichi Mikuri Immunological Lab. Co, Minamikamei-Cho 1-3-43, 581-0054, Yao, Japan aut Kimura Emi Mikuri Immunological Lab. Co, Minamikamei-Cho 1-3-43, 581-0054, Yao, Japan aut Inoue Keisuke Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, 569-8686, Takatsuki, Japan aut Andoh Akira Division of Mucosal Immunology, Graduate School of Medicine, Shiga University of Medical Science, Seta Tukinowa, 520-2192, Otsu, Japan aut Tamai Hiroshi Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, 569-8686, Takatsuki, Japan aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2372-2377 0163-2116 56:8<2372 2011 56 10620 https://doi.org/10.1007/s10620-011-1633-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1633-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Aomatsu Tomoki Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, 569-8686, Takatsuki, Japan aut NATIONALLICENCE 700 1- Yoden Atsushi Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, 569-8686, Takatsuki, Japan aut NATIONALLICENCE 700 1- Matsumoto Kyoichi Mikuri Immunological Lab. Co, Minamikamei-Cho 1-3-43, 581-0054, Yao, Japan aut NATIONALLICENCE 700 1- Kimura Emi Mikuri Immunological Lab. Co, Minamikamei-Cho 1-3-43, 581-0054, Yao, Japan aut NATIONALLICENCE 700 1- Inoue Keisuke Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, 569-8686, Takatsuki, Japan aut NATIONALLICENCE 700 1- Andoh Akira Division of Mucosal Immunology, Graduate School of Medicine, Shiga University of Medical Science, Seta Tukinowa, 520-2192, Otsu, Japan aut NATIONALLICENCE 700 1- Tamai Hiroshi Department of Pediatrics, Osaka Medical College, Daigaku-Cho 2-7, 569-8686, Takatsuki, Japan aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2372-2377 0163-2116 56:8<2372 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer