caa a22 4500 445796286 CHVBK 20180317145126.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1587-0 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1587-0 The Regulation of Thymic Stromal Lymphopoietin in Gut Immune Homeostasis [Elektronische Daten] [Ming Li, Ji Zhang, Yuzhang Wu, Jintao Li] Thymic stromal lymphopoietin is a novel IL-7-like cytokine that exerts immunomodulatory effects and is constitutively expressed by intestinal epithelial cells in response to commensal bacteria colonization. Thymic stromal lymphopoietin can directly or indirectly promote Th2 and Treg responses, and is believed to inhibit Th1 and Th17 responses and limit the expression of proinflammatory cytokines such as IL-17 and IFN-γ. In response to infection by enteric pathogens, intestinal epithelial cells upregulate thymic stromal lymphopoietin expression in order to generate balance between inflammation and immune clearance. Recently, however, aberrant expression of thymic stromal lymphopoietin has been associated with inflammatory bowel disease. Thus, we sought to examine the relationship between the TLSP-TSLPR pathway and inflammation in hopes of contributing to the search for a novel therapeutic target to treat a variety of inflammatory diseases, including inflammatory bowel disease. Springer Science+Business Media, LLC, 2011 Thymic stromal lymphopoietin nationallicence Intestinal nationallicence Immune homeostasis nationallicence IBD nationallicence Li Ming Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, 400038, Shapingba District, Chongqing, People's Republic of China aut Zhang Ji Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, 400038, Shapingba District, Chongqing, People's Republic of China aut Wu Yuzhang Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, 400038, Shapingba District, Chongqing, People's Republic of China aut Li Jintao Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, 400038, Shapingba District, Chongqing, People's Republic of China aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2215-2220 0163-2116 56:8<2215 2011 56 10620 https://doi.org/10.1007/s10620-011-1587-0 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1587-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Li Ming Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, 400038, Shapingba District, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Ji Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, 400038, Shapingba District, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Wu Yuzhang Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, 400038, Shapingba District, Chongqing, People's Republic of China aut NATIONALLICENCE 700 1- Li Jintao Institute of Immunology, PLA, Third Military Medical University, 30 Gaotanyan Street, 400038, Shapingba District, Chongqing, People's Republic of China aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2215-2220 0163-2116 56:8<2215 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer