caa a22 4500 445796308 CHVBK 20180317145126.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1681-3 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1681-3 Lower Serum Level of Adiponectin Is Associated with Increased Risk of Endoscopic Erosive Gastritis [Elektronische Daten] [Shunsuke Yamamoto, Kenji Watabe, Shusaku Tsutsui, Shinichi Kiso, Toshimitsu Hamasaki, Motohiko Kato, Yoshihiro Kamada, Yuichi Yoshida, Shinji Kihara, Miyuki Umeda, Aiko Furubayashi, Kazuo Kinoshita, Osamu Kishida, Takashi Fujimoto, Akira Yamada, Yoshifumi Tsukamoto, Norio Hayashi, Yuji Matsuzawa] Background: Obesity is recently known as a risk factor for endoscopic gastritis. Adiponectin is an anti-inflammatory cytokine secreted from fat tissue, and its serum concentrations are reduced in obesity. The relation between adiponectin and gastritis remains unclear. Aims: The aim of this study was to determine whether lower serum adiponectin level is associated with the risk of endoscopic gastritis. Methods: We analyzed medical records of participants of a routine health check-up examination. Association among endoscopic findings, serum adiponectin level, and other clinical factors including age, sex, alcohol habit, smoking habit, body mass index (BMI), blood pressure, cholesterol, triglyceride, glucose, and insulin were investigated. Endoscopic erosive gastritis was defined as a flat or minimally depressed white spot surrounded by a reddish area or small elevation with central umbilications mimicking octopus' suckers. Results: A total of 2,400 participants were enrolled. BMI was significantly higher in gastritis-positive participants than in gastritis-negative participants. Serum adiponectin levels were significantly lower in gastritis-positive participants than in gastritis-negative participants. Multivariate logistic regression analysis revealed that lower serum adiponectin level (OR 0.96; 95% CI 0.93-0.99), smoking (OR 0.50; 95% CI 0.30-0.80), higher blood pressure (OR 1.02; 95% CI 1.01-1.03), and duodenitis (OR 1.8; 95% CI 1.00-3.09) were significantly associated with endoscopic erosive gastritis. Conclusions: Lower serum level of adiponectin may increase the risk of endoscopic erosive gastritis, independently of BMI. Our findings facilitate further study to clarify the role of hypoadiponectinemia in erosive gastritis. Springer Science+Business Media, LLC, 2011 Erosive gastritis nationallicence Adiponectin nationallicence Obesity nationallicence Health check-up examination nationallicence Yamamoto Shunsuke Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Watabe Kenji Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Tsutsui Shusaku Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Hamasaki Toshimitsu Department of Biomedical Statistics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kato Motohiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kamada Yoshihiro Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Yoshida Yuichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Kihara Shinji Department of Biomedical Informatics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut Umeda Miyuki Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut Furubayashi Aiko Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut Kinoshita Kazuo Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut Kishida Osamu Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut Fujimoto Takashi Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut Yamada Akira Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut Tsukamoto Yoshifumi Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut Hayashi Norio Kansai Rosai Hospital, 3-1-69 Inabashou, 660-8511, Amagasaki, Hyogo, Japan aut Matsuzawa Yuji Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2354-2360 0163-2116 56:8<2354 2011 56 10620 https://doi.org/10.1007/s10620-011-1681-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1681-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yamamoto Shunsuke Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Watabe Kenji Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Tsutsui Shusaku Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kiso Shinichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Hamasaki Toshimitsu Department of Biomedical Statistics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kato Motohiko Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kamada Yoshihiro Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Yoshida Yuichi Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kihara Shinji Department of Biomedical Informatics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Umeda Miyuki Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Furubayashi Aiko Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Kinoshita Kazuo Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Kishida Osamu Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Fujimoto Takashi Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Yamada Akira Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Tsukamoto Yoshifumi Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut NATIONALLICENCE 700 1- Hayashi Norio Kansai Rosai Hospital, 3-1-69 Inabashou, 660-8511, Amagasaki, Hyogo, Japan aut NATIONALLICENCE 700 1- Matsuzawa Yuji Sumitomo Hospital, 5-3-20 Nakanoshima, 530-0005, Kita-ku, Osaka, Japan aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2354-2360 0163-2116 56:8<2354 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer