caa a22 4500 445796405 CHVBK 20180317145126.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1623-0 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1623-0 The Effect of Nicorandil on Small Intestinal Ischemia-Reperfusion Injury in a Canine Model [Elektronische Daten] [Yujin Suto, Kiyohiro Oshima, Kazuhisa Arakawa, Hiroaki Sato, Hodaka Yamazaki, Koshi Matsumoto, Izumi Takeyoshi] Background: It has been shown that nicorandil, which has both ATP-sensitive K+ (KATP) channel opener-like and nitrate-like properties, has an organ-protective effect in ischemia-reperfusion injury in several experimental animal models. Aims: We evaluate the effectiveness of nicorandil on warm ischemia-reperfusion injury of the small intestine in a canine model. Methods: Eighteen beagle dogs were divided into three groups: the control group (n=6); the nicorandil group (n=6), to which nicorandil was injected intravenously before the ischemia; and the glibenclamide group (n=6), to which glibenclamide, which closes the KATP channel and does not suppress the nitrate effect of nicorandil, was orally administered, and then nicorandil was injected in the same manner as in the nicorandil group. Both the superior mesenteric artery and vein were clamped for 2h. Superior mesenteric artery blood flow, small intestinal mucosal tissue blood flow, intramucosal pH, and histopathological analyses were compared among the three groups. Results: Superior mesenteric artery blood flow, mucosal tissue blood flow and pHi after reperfusion were significantly maintained in the nicorandil in comparison with the control and the glibenclamide groups. The histopathological findings showed less severe mucosal damage after reperfusion in the nicorandil group compared with the other two groups. Between the control group and the glibenclamide group, no significant differences were observed in all those parameters. Conclusion: This study suggests that nicorandil has a protective effect on small intestinal IR injury, and activation of KATP channels plays an important role in inhibiting small intestinal IR injury. Springer Science+Business Media, LLC, 2011 Nicorandil nationallicence KATP channel opener nationallicence Glibenclamide nationallicence Ischemia-reperfusion injury nationallicence Small intestine nationallicence Suto Yujin Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Oshima Kiyohiro Department of Emergency Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan aut Arakawa Kazuhisa Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Sato Hiroaki Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Yamazaki Hodaka Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Matsumoto Koshi CML Pathological Research, Kanagawa, Japan aut Takeyoshi Izumi Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2276-2282 0163-2116 56:8<2276 2011 56 10620 https://doi.org/10.1007/s10620-011-1623-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1623-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Suto Yujin Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Oshima Kiyohiro Department of Emergency Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan aut NATIONALLICENCE 700 1- Arakawa Kazuhisa Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Sato Hiroaki Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Yamazaki Hodaka Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 700 1- Matsumoto Koshi CML Pathological Research, Kanagawa, Japan aut NATIONALLICENCE 700 1- Takeyoshi Izumi Department of Thoracic and Visceral Organ Surgery, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, 371-8511, Maebashi, Gunma, Japan aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2276-2282 0163-2116 56:8<2276 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer