caa a22 4500 445796499 CHVBK 20180317145127.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1616-z doi (NATIONALLICENCE)springer-10.1007/s10620-011-1616-z CT Portography with Gastric Variceal Volume Measurements in the Evaluation of Endoscopic Therapeutic Efficacy of Tissue Adhesive Injection into Gastric Varices: A Pilot Study [Elektronische Daten] [John Rice, Meghan Lubner, Andrew Taylor, Bret Spier, Adnan Said, Michael Lucey, Alexandru Musat, Mark Reichelderfer, Patrick Pfau, Deepak Gopal] Background: N-butyl-2-cyanoacrylate (NBCA) injection is used for treating gastric varices (GV). Determining the degree of obliteration of GV is not readily evident at endoscopy. Aims: The aim of this study was to evaluate CT portography with gastric variceal volume calculations to assess endoscopic therapeutic efficacy of NBCA injection. Methods: The study design is a retrospective series pilot study. The setting is a single, tertiary care academic medical center. Ten patients underwent esophagogastroduodenoscopy (EGD) with NBCA injection of GV and had biphasic CT scans performed before and after injection therapy. Based on portal venous images, 3D reconstruction and semi-automated volume calculations of GV were performed. Pre and post injection GV volume calculations were compared. Results: The mean pre-procedure GV volume was 89.84cm3. Eight patients had significant improvement in GV volume from pre-treatment versus post-treatment (95.65cm3 vs. 49.65cm3, P-value 0.04). Pre-procedure GV volume was not significantly different in patients treated for active hemorrhage versus no hemorrhage (101.66cm3 vs. 72.11cm3, P-value 0.33). Two patients had a subsequent GV hemorrhage after NBCA injection. The mean residual GV volume in these patients versus those that did not re-bleed was significantly more (127.77cm3 vs. 38.00cm3, P-value 0.005). Conclusions: CT portography with measurement of GV volume is a potentially useful tool in determining the therapeutic efficacy NBCA injection of GV. Patients with higher residual GV volumes are at increased risk of hemorrhage and may benefit from repeat injection to reach ideal GV volumes. Springer Science+Business Media, LLC, 2011 Gastric varices nationallicence N-butyl-cyanoacrylate tissue adhesive nationallicence Multi-detector (MD) CT-portography nationallicence Therapeutic endoscopy nationallicence Gastric variceal volume calculations nationallicence Rice John Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut Lubner Meghan Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut Taylor Andrew Department of Radiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA aut Spier Bret Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut Said Adnan Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut Lucey Michael Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut Musat Alexandru Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut Reichelderfer Mark Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut Pfau Patrick Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut Gopal Deepak Division of Gastroenterology & Hepatology, University of Wisconsin School of Medicine & Public Health, Room # 4229 UWMF Centennial Building, 1685 Highland Avenue, 53705, Madison, WI, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2466-2472 0163-2116 56:8<2466 2011 56 10620 https://doi.org/10.1007/s10620-011-1616-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1616-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rice John Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut NATIONALLICENCE 700 1- Lubner Meghan Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA aut NATIONALLICENCE 700 1- Taylor Andrew Department of Radiology, Virginia Commonwealth University School of Medicine, Richmond, VA, USA aut NATIONALLICENCE 700 1- Spier Bret Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut NATIONALLICENCE 700 1- Said Adnan Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut NATIONALLICENCE 700 1- Lucey Michael Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut NATIONALLICENCE 700 1- Musat Alexandru Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut NATIONALLICENCE 700 1- Reichelderfer Mark Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut NATIONALLICENCE 700 1- Pfau Patrick Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, H6/516 Clinical Science Center, 600 Highland Avenue, 53792-5124, Madison, WI, USA aut NATIONALLICENCE 700 1- Gopal Deepak Division of Gastroenterology & Hepatology, University of Wisconsin School of Medicine & Public Health, Room # 4229 UWMF Centennial Building, 1685 Highland Avenue, 53705, Madison, WI, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2466-2472 0163-2116 56:8<2466 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer