caa a22 4500 445796502 CHVBK 20180317145127.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1598-x doi (NATIONALLICENCE)springer-10.1007/s10620-011-1598-x Prevalence of Advanced Adenomas in Small and Diminutive Colon Polyps Using Direct Measurement of Size [Elektronische Daten] [Franklin Tsai, Williamson Strum] Background and Aims: Most studies reporting polyp size use visual estimates. Determining the prevalence of advanced histology based on direct measurement of polyp size may help guide the management of polyps found at optical colonoscopy (OC) and CT colonography (CTC). Methods: We designed a large, prospective study to assess the prevalence of advanced adenomas based on direct measurement of polyp size by a certified pathologists' assistant as reported in the pathology report. Patients between 40 and 89 years of age who presented for screening colonoscopy were included in our study. Advanced adenomas were defined as ≥10mm or ≥25% villous features, high grade dysplasia or cancer. Polyps were divided by size into three groups: diminutive (≤5mm), small (6-9mm) and large (≥10mm). If more than one adenoma was present, the most advanced was used for analysis. Results: We evaluated 6,905 consecutive patients referred for colonoscopy between January 2005 and December 2006. Of the 4,967 who met the inclusion criteria, the mean age was 58.8 and consisted of 59% women. Overall, 930 (18.7%) had an adenoma; 248 (5%) were advanced adenomas including 8 (0.16%) cancers. Of 89 polyps ≥10mm, 76 (85%) had advanced histology; of 247 polyps 6-9mm, 67 (27%) were advanced; of 1,025 polyps ≤5mm, 105 (10%) were advanced. Thus, 172 of 248 (69%) patients with advanced adenomas had small or diminutive adenomas. Conclusions: Our data indicate the majority (69%) of advanced adenomas are <10mm. Even among polyps ≤5mm, there was an appreciable prevalence of advanced adenomas (10%). These findings may help guide the management of sub-centimeter colon polyps found by OC or CTC. Springer Science+Business Media, LLC, 2011 Advanced adenoma nationallicence Polyp size nationallicence Screening colonoscopy nationallicence CT colonography nationallicence Tsai Franklin Division of Gastroenterology, Scripps Clinic and the Scripps Clinic Research Institute, Torrey Pines, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Strum Williamson Division of Gastroenterology, Scripps Clinic and the Scripps Clinic Research Institute, Torrey Pines, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2384-2388 0163-2116 56:8<2384 2011 56 10620 https://doi.org/10.1007/s10620-011-1598-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1598-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsai Franklin Division of Gastroenterology, Scripps Clinic and the Scripps Clinic Research Institute, Torrey Pines, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Strum Williamson Division of Gastroenterology, Scripps Clinic and the Scripps Clinic Research Institute, Torrey Pines, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2384-2388 0163-2116 56:8<2384 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer