caa a22 4500 445796618 CHVBK 20180317145127.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1634-x doi (NATIONALLICENCE)springer-10.1007/s10620-011-1634-x Nicorandil Associated Colonic Ulceration: Case Series of an Increasingly Recognized Complication [Elektronische Daten] [Bee Lee, Patrick Allen, Grant Caddy, Inder Mainie] Background: Nicorandil is widely accepted in the therapeutic armamentarium of ischemic heart disease and, although nicorandil-induced oral and anal ulcerations have been established in the literature, only five cases have reported the possibility of nicorandil-induced ulceration elsewhere in the gastrointestinal tract. There have been recent case reports which have suggested the possible causative association between nicorandil and colonic ulceration, either in isolation or in combination with anal ulceration. Methods: We report a case series of eight patients prescribed with nicorandil therapy presenting with gastrointestinal symptoms and subsequently diagnosed with colonic ulceration on colonoscopy. Results: Eight patients were identified (five female, three male). Colonoscopic findings varied from solitary to multiple colonic ulcers. No concomitant oral or anal ulcerations were noted in these patients. Biopsies from the ulcers showed only non-specific inflammation. Cessation of nicorandil therapy resulted in resolution of symptoms and complete healing of colonic ulcers. Conclusion: Nicorandil therapy appears to be an emerging etiology in the development of idiopathic colonic ulceration and therefore should be considered as a differential diagnosis in a selected group of patients. Springer Science+Business Media, LLC, 2011 Nicorandil nationallicence Colon nationallicence Ulcer nationallicence Colonic ulceration nationallicence Lee Bee Department of Gastroenterology, Downe Hospital, South Eastern Health and Social Care Trust, 2 Struell Wells Road, BT30 6RL, Downpatrick, Northern Ireland, UK aut Allen Patrick Department of Gastroenterology, Belfast City Hospital, Belfast Health and Social Care Trust, 51 Lisburn Road, BT9 7ER, Belfast, Northern Ireland, UK aut Caddy Grant Department of Gastroenterology, Ulster Hospital, South Eastern Health and Social Care Trust, Upper Newtownards Road, BT16 1RH, Dundonald, Belfast, Northern Ireland, UK aut Mainie Inder Department of Gastroenterology, Belfast City Hospital, Belfast Health and Social Care Trust, 51 Lisburn Road, BT9 7ER, Belfast, Northern Ireland, UK aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2404-2408 0163-2116 56:8<2404 2011 56 10620 https://doi.org/10.1007/s10620-011-1634-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1634-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Bee Department of Gastroenterology, Downe Hospital, South Eastern Health and Social Care Trust, 2 Struell Wells Road, BT30 6RL, Downpatrick, Northern Ireland, UK aut NATIONALLICENCE 700 1- Allen Patrick Department of Gastroenterology, Belfast City Hospital, Belfast Health and Social Care Trust, 51 Lisburn Road, BT9 7ER, Belfast, Northern Ireland, UK aut NATIONALLICENCE 700 1- Caddy Grant Department of Gastroenterology, Ulster Hospital, South Eastern Health and Social Care Trust, Upper Newtownards Road, BT16 1RH, Dundonald, Belfast, Northern Ireland, UK aut NATIONALLICENCE 700 1- Mainie Inder Department of Gastroenterology, Belfast City Hospital, Belfast Health and Social Care Trust, 51 Lisburn Road, BT9 7ER, Belfast, Northern Ireland, UK aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2404-2408 0163-2116 56:8<2404 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer