caa a22 4500 445796634 CHVBK 20180317145127.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1631-0 doi (NATIONALLICENCE)springer-10.1007/s10620-011-1631-0 Esophageal Contractions in Patients with Chronic Progressive External Ophthalmoplegia [Elektronische Daten] [Danielle Domenis, Paula Okubo, Cláudia Sobreira, Roberto Dantas] Background: Chronic progressive external ophthalmoplegia is a mitochondrial myopathy that causes muscular or multisystem symptoms and has dysphagia as one manifestation. Aim: To evaluate esophageal contractions in patients with chronic progressive external ophthalmoplegia. Methods: We studied 14 patients with chronic progressive external ophthalmoplegia and 16 asymptomatic volunteers. The diagnosis of the disease was established by the clinical picture and by mitochondrial DNA analysis in skeletal muscle. We used the manometric method with a perfusion catheter that recorded the esophageal contractions at 2, 7, 12, 17, and 22cm from the lower esophageal sphincter (LES). All subjects performed in the supine position 20 swallows of a 5-ml bolus of water at room temperature, ten every 30s and ten every 10s. Results: The amplitude, duration, and area under the curve of contractions at 17 and 22cm from the LES were lower in patients than in volunteers for swallows performed at 10-s and 30-s intervals (P<0.01). There was no difference in contractions at 7 and 2cm, except for the contractions at 2cm after swallows performed at 30-s intervals. The interval between the onset of contractions between 7 and 2cm and between 22 and 2cm was lower in patients than in volunteers, with swallows performed every 10s and every 30s. Conclusion: There is impairment of esophageal contractions in patients with chronic progressive external ophthalmoplegia, mainly in the proximal esophageal body. Springer Science+Business Media, LLC, 2011 Chronic progressive external ophthalmoplegia nationallicence Dysphagia nationallicence Mitochondrial myopathy nationallicence Esophageal manometry nationallicence Esophageal motility nationallicence Domenis Danielle Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil aut Okubo Paula Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil aut Sobreira Cláudia Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil aut Dantas Roberto Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2343-2348 0163-2116 56:8<2343 2011 56 10620 https://doi.org/10.1007/s10620-011-1631-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1631-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Domenis Danielle Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Okubo Paula Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Sobreira Cláudia Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 700 1- Dantas Roberto Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2343-2348 0163-2116 56:8<2343 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer