caa a22 4500 445796677 CHVBK 20180317145127.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10620-011-1625-y doi (NATIONALLICENCE)springer-10.1007/s10620-011-1625-y Gut-Brain Chemokine Changes in Portal Hypertensive Rats [Elektronische Daten] [Joaquin Merino, Maria-Angeles Aller, Sandra Rubio, Natalia Arias, Maria-Paz Nava, Maria Loscertales, Jaime Arias, Jorge-Luis Arias] Background: Hepatic encephalopathy is a syndrome whose physiopathology is poorly understood; therefore, current diagnostic tests are imperfect and modern therapy is nonspecific. Particularly, it has been suggested that inflammation plays an important role in the pathogenesis of portal hypertensive encephalopathy in the rat. Aim: We have studied an experimental model of portal hypertension based on a triple partial portal vein ligation in the rat to verify this hypothesis. Methods: One month after portal hypertension we assayed in the splanchnic area (liver, small bowel and mesenteric lymph nodes) and in the central nervous system (hippocampus and cerebellum) fractalkine (CX3CL1) and stromal cell-derived factor alpha (SDF1-α) as well as their respective receptors (CX3CR1 and CXCR4) because of their key role in inflammatory processes. Results: The significant increase of fractalkine in mesenteric lymph nodes (P<0.05) and its receptor (CX3CR1) in the small bowel (P<0.05) and hippocampus (P<0.01), associated with the increased expression of SDF1-α in the hippocampus (P<0.01) and the cerebellum (P<0.01) suggest that prehepatic portal hypertension in the rat induces important alterations in the expression of chemokines in the gut-brain axis. Conclusion: The present study revealed that portal hypertension is associated with splanchnic-brain inflammatory alterations mediated by chemokines. Springer Science+Business Media, LLC, 2011 Chemokines nationallicence Hepatic encephalopathy nationallicence Neuroinflammation nationallicence CXCR4/SDF1-alpha nationallicence CXCR1/Fractalkine nationallicence Rat nationallicence Merino Joaquin Department of Surgery I, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n, 28040, Madrid, Spain aut Aller Maria-Angeles Department of Surgery I, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n, 28040, Madrid, Spain aut Rubio Sandra Department of Psychobiology, School of Psychology, Autonomous University of Madrid, 28049, Cantoblanco, Madrid, Spain aut Arias Natalia Neurosciences Laboratory, School of Psychology, University of Oviedo, Pza. de Feijoo s/n, 33003, Oviedo, Asturias, Spain aut Nava Maria-Paz Department of Physiology (Animal Physiology II), School of Biology, Complutense University of Madrid, J. A. Novais 2, 28040, Madrid, Spain aut Loscertales Maria Department of Surgery, Massachusetts General Hospital, 1055 Fruit St., 02114, Boston, MA, USA aut Arias Jaime Department of Surgery I, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n, 28040, Madrid, Spain aut Arias Jorge-Luis Neurosciences Laboratory, School of Psychology, University of Oviedo, Pza. de Feijoo s/n, 33003, Oviedo, Asturias, Spain aut Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2309-2317 0163-2116 56:8<2309 2011 56 10620 https://doi.org/10.1007/s10620-011-1625-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10620-011-1625-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Merino Joaquin Department of Surgery I, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Aller Maria-Angeles Department of Surgery I, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Rubio Sandra Department of Psychobiology, School of Psychology, Autonomous University of Madrid, 28049, Cantoblanco, Madrid, Spain aut NATIONALLICENCE 700 1- Arias Natalia Neurosciences Laboratory, School of Psychology, University of Oviedo, Pza. de Feijoo s/n, 33003, Oviedo, Asturias, Spain aut NATIONALLICENCE 700 1- Nava Maria-Paz Department of Physiology (Animal Physiology II), School of Biology, Complutense University of Madrid, J. A. Novais 2, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Loscertales Maria Department of Surgery, Massachusetts General Hospital, 1055 Fruit St., 02114, Boston, MA, USA aut NATIONALLICENCE 700 1- Arias Jaime Department of Surgery I, School of Medicine, Complutense University of Madrid, Plaza de Ramón y Cajal s.n, 28040, Madrid, Spain aut NATIONALLICENCE 700 1- Arias Jorge-Luis Neurosciences Laboratory, School of Psychology, University of Oviedo, Pza. de Feijoo s/n, 33003, Oviedo, Asturias, Spain aut NATIONALLICENCE 773 0- Digestive Diseases and Sciences Springer US; http://www.springer-ny.com 56/8(2011-08-01), 2309-2317 0163-2116 56:8<2309 2011 56 10620 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer